Published on in Vol 13 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/83352, first published .
Prediction of 12-Week Remission in Patients With Depressive Disorder Using Reasoning-Based Large Language Models: Model Development and Validation Study

Prediction of 12-Week Remission in Patients With Depressive Disorder Using Reasoning-Based Large Language Models: Model Development and Validation Study

Prediction of 12-Week Remission in Patients With Depressive Disorder Using Reasoning-Based Large Language Models: Model Development and Validation Study

Jin-Hyun Park   1 * , MSc ;   Hee-Ju Kang   2 * , MD, PhD ;   Ji Hyeon Jeon   2 , MD ;   Sung-Gil Kang   2 , MD ;   Ju-Wan Kim   2 , MSc, MD ;   Jae-Min Kim   2 , MD, PhD ;   Hwamin Lee   1 , PhD

1 Department of Biomedical Informatics, Korea University College of Medicine, Seoul, Republic of Korea

2 Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea

*these authors contributed equally

Corresponding Author:

  • Hwamin Lee, PhD
  • Department of Biomedical Informatics
  • Korea University College of Medicine
  • 161, Jeongneung-ro, Seongbuk-gu
  • Seoul 02708
  • Republic of Korea
  • Phone: 82 2-3407-2099
  • Email: hwamin@korea.ac.kr