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This paper is in the following e-collection/theme issue:

Theme Issue 2025: AI-Powered Therapy Bots and Virtual Companions in Digital Mental Health (88) Depression and Mood Disorders; Suicide Prevention (2557) Anxiety and Stress Disorders (1674) Chatbots and Conversational Agents (1262)

Published on in Vol 13 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/82642, first published .
Woman on a video call with a smiling blonde woman on a smartphone.

Effectiveness of a Fully Automated Mobile Therapeutic Versus a General Chatbot in Reducing Depression and Anxiety and Improving Well-Being: Feasibility Randomized Controlled Trial

Effectiveness of a Fully Automated Mobile Therapeutic Versus a General Chatbot in Reducing Depression and Anxiety and Improving Well-Being: Feasibility Randomized Controlled Trial

Authors of this article:

Barbora Kuta1 Author Orcid Image ;   Lukas Novak1 Author Orcid Image ;   Radka Zidkova1 Author Orcid Image ;   Jana Furstova1 Author Orcid Image ;   Klara Malinakova1 Author Orcid Image ;   Andrea De Winter2 Author Orcid Image ;   Vít Husek1 Author Orcid Image
Article Authors Cited by (8) Tweetations (2) Metrics

Journals

  1. Nelson B, Kalinich M, Torous J. Specialized or General-Purpose—The Wrong Question for Mental Health AI Safety. JAMA 2026;336(4):281 View
  2. Birk M, Kochhar S, Myrick K, Schueller S, Torous J. Digital Mental Health Research Priorities, Revisited for the AI and Large Language Model Era. JMIR Mental Health 2026;13:e104118 View
  3. Kahane K, Torous J. Psychiatry, Social Media, Artificial Intelligence: A Call for Engagement. Journal of Psychiatric Practice 2026;32(4):209 View
  4. Giansanti D, Lastrucci A. AI- and Generative AI-Driven Digital Therapeutics: A Critical Narrative Review of Emerging Evidence. AI 2026;7(8):296 View
  5. Haroz E, Bradshaw C, Feaster D. Introduction to the Special Issue on Transforming Prevention Science: Advances and Applications of Artificial Intelligence and Related Methods. Prevention Science 2026;27(7):1015 View
  6. Hamlin M, Wartenberg C, Ali L, Aiff H, Wesén L, Sjögren P, Svanberg T, Wentz E, Steingrimsson S. The potential of digitalized follow-up care in depression treated with pharmacotherapy: A scoping review. DIGITAL HEALTH 2026;12 View
  7. Jaroszewski A, Jonathan G, Jones G, Patel A, Jacoby R, Wilhelm S. Randomized controlled trials evaluating generative artificial intelligence-enabled mental health interventions among samples with clinically significant baseline symptoms: a systematic review and narrative synthesis. Clinical Psychology Review 2026:102814 View

Conference Proceedings

  1. Agarwal S. 2026 IEEE 13th International Conference on Intelligent Systems (IS). Large Language Models in Mental Health Support and Psychotherapy Chatbots: Clinical Applications, Evidence Base, Ethical Risks, and Governance Priorities View