AI-Powered Therapy Bots and Virtual Companions in Digital Mental Health

Articles published in this theme: 34 (scroll down to load remaining articles)

2026

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AI Chatbots for Mental Health Self-Management: Lived Experience–Centered Qualitative Study

Dong Whi Yoo, Jiayue Melissa Shi, Violeta J Rodriguez, Koustuv Saha

JMIR Ment Health 2026 (Apr 02); 13:e78288

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Real-World Use of a Mental Health AI Companion: Multiple Methods Study

Christine Callahan, Leah Tanner, Chelsea Coe, Michelle Davis, Jenna Glover, Ellis Bernstein, Katherine Scranton, Kenli Urruty, Matthew Chester, Sarah Kunkle

JMIR Form Res 2026 (Feb 13); 10:e86904

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2025

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Physician Perspectives on the Impact of Artificial Intelligence on the Therapeutic Relationship in Mental Health Care: Qualitative Study

Isabel B Weir, Austin M Stroud, Jeremiah J Stout, Barbara A Barry, Arjun P Athreya, William V Bobo, Richard R Sharp

JMIR Ment Health 2025 (Dec 30); 12:e81970

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ChatGPT Clinical Use in Mental Health Care: Scoping Review of Empirical Evidence

Raluca Balan, Thomas P Gumpel

JMIR Ment Health 2025 (Dec 24); 12:e81204

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Investigating How Clinicians Form Trust in an AI-Based Mental Health Model: Qualitative Case Study

Anthony Kelly, Niharika Bhardwaj, Trine Theresa Holmberg Sainte-Marie, Pepijn Van de Ven, Ruth Melia, John Eustis Williams, Kim Mathiasen, Amalie Søgaard Nielsen

JMIR Hum Factors 2025 (Dec 19); 12:e79658

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A Paradigm Shift in Progress: Generative AI’s Evolving Role in Mental Health Care

John Torous, Andrea Cipriani

JMIR Ment Health 2025 (Dec 17); 12:e82369

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Evaluating Generative AI Psychotherapy Chatbots Used by Youth: Cross-Sectional Study

Kunmi Sobowale, Daniel Kevin Humphrey, Sophia Yingruo Zhao

JMIR Ment Health 2025 (Dec 10); 12:e79838

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AI-Facilitated Cognitive Reappraisal via Socrates 2.0: Mixed Methods Feasibility Study

Philip Held, Sarah A Pridgen, Daniel R Szoke, Yaozhong Chen, Zuhaib Akhtar, Darpan Amin

JMIR Ment Health 2025 (Dec 05); 12:e80461

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Delusional Experiences Emerging From AI Chatbot Interactions or “AI Psychosis”

Alexandre Hudon, Emmanuel Stip

JMIR Ment Health 2025 (Dec 03); 12:e85799

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Clinical Efficacy, Therapeutic Mechanisms, and Implementation Features of Cognitive Behavioral Therapy–Based Chatbots for Depression and Anxiety: Narrative Review

Chang-Ha Im, Minjung Woo

JMIR Ment Health 2025 (Nov 28); 12:e78340

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Seeking Emotional and Mental Health Support From Generative AI: Mixed-Methods Study of ChatGPT User Experiences

Xiaochen Luo, Zixuan Wang, Jacqueline L Tilley, Sanjeev Balarajan, Ukeme-Abasi Bassey, Choi Ieng Cheang

JMIR Ment Health 2025 (Nov 27); 12:e77951

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The Effectiveness of AI Chatbots in Alleviating Mental Distress and Promoting Health Behaviors Among Adolescents and Young Adults: Systematic Review and Meta-Analysis

Xinyu Feng, Lidan Tian, Grace W K Ho, Janelle Yorke, Vivian Hui

J Med Internet Res 2025 (Nov 26); 27:e79850

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Chatbots’ Empathetic Conversations and Responses: A Qualitative Study of Help‑Seeking Queries on Depressive Moods Across 8 Commercial Conversational Agents

Hyojin Chin, Gumhee Baek, Chiyoung Cha, Meeyoung Cha

JMIR Form Res 2025 (Nov 24); 9:e71538

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Smartphone Apps for Cardiovascular and Mental Health Care: Digital Cross-Sectional Analysis

Manjot Singh, Julian Herpertz, Noy Alon, Sarah Perret, John Torous, Daniel Kramer

JMIR Mhealth Uhealth 2025 (Nov 13); 13:e63642

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A Prompt Engineering Framework for Large Language Model–Based Mental Health Chatbots: Conceptual Framework

Sorio Boit, Rajvardhan Patil

JMIR Ment Health 2025 (Nov 07); 12:e75078

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“It’s Not Only Attention We Need”: Systematic Review of Large Language Models in Mental Health Care

Andreas Bucher, Sarah Egger, Inna Vashkite, Wenyuan Wu, Gerhard Schwabe

JMIR Ment Health 2025 (Nov 04); 12:e78410

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Governing AI in Mental Health: 50-State Legislative Review

J Nicholas Shumate, Eden Rozenblit, Matthew Flathers, Carlos A Larrauri, Christine Hau, Winna Xia, E Nicholas Torous, John Torous

JMIR Ment Health 2025 (Oct 31); 12:e80739

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Behavior Emotion Therapy System and You: Co-Design and Evaluation of a Mental Health Chatbot and Digital Human for Mild to Moderate Anxiety in Healthy Participants

Almira Osmanovic Thunström, Lilas Ali, Hanne Krage Carlsen, Maria Bohm, Linda Wesén, Olof Wrede, Iris Sarajlic Vukovic, Andreas Hellström, Tomas Larson, Steinn Steingrimsson

JMIR Form Res 2025 (Oct 30); 9:e66163

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Preprocessing Large-Scale Conversational Datasets: A Framework and Its Application to Behavioral Health Transcripts

Paz Mor Naim, Shiri Sadeh-Sharvit, Samuel Jefroykin, Eddie Silber, Dennis P Morrison, Ariel Goldstein

JMIR Form Res 2025 (Oct 24); 9:e78082

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Effectiveness, Engagement, and Safety of a Digital Therapeutic (CT-155/BI 3972080) for Treating Negative Symptoms in People With Schizophrenia: Protocol for the Phase 3 CONVOKE Randomized Controlled Trial

Shaheen E Lakhan, Cornelia Dorner-Ciossek, Olya Besedina, Faith Dickerson, Claudia Hastedt, Ridwana Isla, René S Kahn, Jean-Pierre Lindenmayer, Ruchi Mehta, Cassandra Snipes, Austin Speier, Wenbo Tang, Bailey Willis, Jamie Winderbaum Fernandez, Christoph von der Goltz, Abhishek Pratap

JMIR Res Protoc 2025 (Oct 07); 14:e81293

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