AI-Powered Therapy Bots and Virtual Companions in Digital Mental Health

Artificial Intelligence in Mental Health Services Under Illinois Public Act 104‐0054: Legal Boundaries and a Framework for Establishing Safe, Effective AI Tools

Daniel Szoke, Sarah Pridgen, Philip Held

J Med Internet Res 2025 (Jan 25); 12(1):e84854

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Delusional Experiences Emerging From AI Chatbot Interactions or “AI Psychosis”

Alexandre Hudon, Emmanuel Stip

JMIR Ment Health 2025 (Dec 03); 12:e85799

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Clinical Efficacy, Therapeutic Mechanisms, and Implementation Features of Cognitive Behavioral Therapy–Based Chatbots for Depression and Anxiety: Narrative Review

Chang-Ha Im, Minjung Woo

JMIR Ment Health 2025 (Nov 28); 12:e78340

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Seeking Emotional and Mental Health Support From Generative AI: Mixed-Methods Study of ChatGPT User Experiences

Xiaochen Luo, Zixuan Wang, Jacqueline L Tilley, Sanjeev Balarajan, Ukeme-Abasi Bassey, Choi Ieng Cheang

JMIR Ment Health 2025 (Nov 27); 12:e77951

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The Effectiveness of AI Chatbots in Alleviating Mental Distress and Promoting Health Behaviors Among Adolescents and Young Adults: Systematic Review and Meta-Analysis

Xinyu Feng, Lidan Tian, Grace W K Ho, Janelle Yorke, Vivian Hui

J Med Internet Res 2025 (Nov 26); 27:e79850

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Chatbots’ Empathetic Conversations and Responses: A Qualitative Study of Help‑Seeking Queries on Depressive Moods Across 8 Commercial Conversational Agents

Hyojin Chin, Gumhee Baek, Chiyoung Cha, Meeyoung Cha

JMIR Form Res 2025 (Nov 24); 9:e71538

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Smartphone Apps for Cardiovascular and Mental Health Care: Digital Cross-Sectional Analysis

Manjot Singh, Julian Herpertz, Noy Alon, Sarah Perret, John Torous, Daniel Kramer

JMIR Mhealth Uhealth 2025 (Nov 13); 13:e63642

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A Prompt Engineering Framework for Large Language Model–Based Mental Health Chatbots: Conceptual Framework

Sorio Boit, Rajvardhan Patil

JMIR Ment Health 2025 (Nov 07); 12:e75078

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“It’s Not Only Attention We Need”: Systematic Review of Large Language Models in Mental Health Care

Andreas Bucher, Sarah Egger, Inna Vashkite, Wenyuan Wu, Gerhard Schwabe

JMIR Ment Health 2025 (Nov 04); 12:e78410

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Governing AI in Mental Health: 50-State Legislative Review

J Nicholas Shumate, Eden Rozenblit, Matthew Flathers, Carlos A Larrauri, Christine Hau, Winna Xia, E Nicholas Torous, John Torous

JMIR Ment Health 2025 (Oct 31); 12:e80739

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Behavior Emotion Therapy System and You: Co-Design and Evaluation of a Mental Health Chatbot and Digital Human for Mild to Moderate Anxiety in Healthy Participants

Almira Osmanovic Thunström, Lilas Ali, Hanne Krage Carlsen, Maria Bohm, Linda Wesén, Olof Wrede, Iris Sarajlic Vukovic, Andreas Hellström, Tomas Larson, Steinn Steingrimsson

JMIR Form Res 2025 (Oct 30); 9:e66163

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Preprocessing Large-Scale Conversational Datasets: A Framework and Its Application to Behavioral Health Transcripts

Paz Mor Naim, Shiri Sadeh-Sharvit, Samuel Jefroykin, Eddie Silber, Dennis P Morrison, Ariel Goldstein

JMIR Form Res 2025 (Oct 24); 9:e78082

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Effectiveness, Engagement, and Safety of a Digital Therapeutic (CT-155/BI 3972080) for Treating Negative Symptoms in People With Schizophrenia: Protocol for the Phase 3 CONVOKE Randomized Controlled Trial

Shaheen E Lakhan, Cornelia Dorner-Ciossek, Olya Besedina, Faith Dickerson, Claudia Hastedt, Ridwana Isla, René S Kahn, Jean-Pierre Lindenmayer, Ruchi Mehta, Cassandra Snipes, Austin Speier, Wenbo Tang, Bailey Willis, Jamie Winderbaum Fernandez, Christoph von der Goltz, Abhishek Pratap

JMIR Res Protoc 2025 (Oct 07); 14:e81293

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Weighing Costs and Benefits of Delay and the Acceptance of Two Decision Support Tools in Mental Health Care: Scoping Study Using Quantitative and Qualitative Data

Sarah McKenna, Min K Chong, Adam Poulsen, Ashlee Turner, Carla Gorban, Jacob J Crouse, William Capon, Mathew Varidel, Melissa Aji, Elizabeth M Scott, Ian B Hickie, Frank Iorfino

JMIR Hum Factors 2025 (Sep 30); 12:e71678

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Exploring Young Adults' Attitudes Toward AI-Driven mHealth Apps: Qualitative Study

Ali Aboueldahab, Gabriele Damaschi, Marco D'Addario, Patrizia Steca

JMIR Hum Factors 2025 (Sep 26); 12:e76075

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Practitioner Perspectives on the Uses of Generative AI Chatbots in Mental Health Care: Mixed Methods Study

Jessie Goldie, Simon Dennis, Lyndsey Hipgrave, Amanda Coleman

JMIR Hum Factors 2025 (Sep 16); 12:e71065

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New Doc on the Block: Scoping Review of AI Systems Delivering Motivational Interviewing for Health Behavior Change

Zev Karve, Jacob Calpey, Christopher Machado, Michelle Knecht, Maria Carmenza Mejia

J Med Internet Res 2025 (Sep 16); 27:e78417

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Effect of a Cognitive Behavioral Therapy–Based AI Chatbot on Depression and Loneliness in Chinese University Students: Randomized Controlled Trial With Financial Stress Moderation

Yahui Wang, Xuhong Li, Qiaochu Zhang, Dannii Yeung, Yihan Wu

JMIR Mhealth Uhealth 2025 (Aug 29); 13:e63806

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“I Believe That AI Will Recognize the Problem Before It Happens”: Qualitative Study Exploring Young Adults’ Perceptions of AI in Mental Health Care

Lena Petersson, Mikael G Ahlborg, Katrin Häggström Westberg

JMIR Ment Health 2025 (Aug 25); 12:e76973

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Exploring the Application of AI and Extended Reality Technologies in Metaverse-Driven Mental Health Solutions: Scoping Review

Aliya Tabassum, Ibrahim Ghaznavi, Alaa Abd-Alrazaq, Junaid Qadir

J Med Internet Res 2025 (Aug 19); 27:e72400

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