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This paper is in the following e-collection/theme issue:

Reviews in Digital Mental Health (312) Ethics, Privacy, and Legal Issues (679) Digital Mental Health Interventions, e-Mental Health and Cyberpsychology (2351) Methods and New Tools in Mental Health Research (609) Mobile Health in Psychiatry (563) Diagnostic Tools in Mental Health (348) Artificial Intelligence (2446) Generative Language Models Including ChatGPT (880) Responsible Health AI (105) AI-Powered Therapy Bots and Virtual Companions in Digital Mental Health (36)

Published on in Vol 12 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/70610, first published .
The Application and Ethical Implication of Generative AI in Mental Health: Systematic Review

The Application and Ethical Implication of Generative AI in Mental Health: Systematic Review

The Application and Ethical Implication of Generative AI in Mental Health: Systematic Review

Authors of this article:

Xi Wang1 Author Orcid Image ;   Yujia Zhou2 Author Orcid Image ;   Guangyu Zhou1 Author Orcid Image
Article Authors Cited by (23) Tweetations (11) Metrics

Journals

  1. Clark A. The Ability of AI Therapy Bots to Set Limits With Distressed Adolescents: Simulation-Based Comparison Study. JMIR Mental Health 2025;12:e78414 View
  2. Wislocki K, Sami S, Liberzon G, Zalta A. Comparing Generative Artificial Intelligence and Mental Health Professionals for Clinical Decision-Making With Trauma-Exposed Populations: Vignette-Based Experimental Study. JMIR Mental Health 2025;12:e80801 View
  3. Pacyna J, Anzabi M, Stroud A, Wise J, Sharp R. Patient concerns about AI-based voice analysis in healthcare. BMC Digital Health 2025;3(1) View
  4. Bodner R, Lim K, Schneider R, Torous J. Efficacy and risks of artificial intelligence chatbots for anxiety and depression: a narrative review of recent clinical studies. Current Opinion in Psychiatry 2026;39(1):19 View
  5. Daovisan H. Unlocking New Insights for Artificial Intelligence in Applied Psychology: A Bibliometric Analysis and Knowledge Mapping Study. Journal of Technology in Behavioral Science 2025 View
  6. Saladie N, Llorente C, Joosten R, Revuelta G. Comparing Images of Depression in Mass Media and AI-Generated Pictures: Mixed Methods Study. JMIR Human Factors 2026;13:e81230 View
  7. Dong J, Chen X, Lyu C, Wu M, Ruan C, Yan F, Zhang D. Attitudes of psychiatric nurses towards the integration of artificial intelligence applications to clinical care: a qualitative study in China. BMC Nursing 2026;25(1) View
  8. Voultsiou E, Moussiades L. A Systematic Review of Large Language Models in Mental Health: Opportunities, Challenges, and Future Directions. Electronics 2026;15(3):524 View
  9. Balcombe L. Digital Mental Health Post COVID-19: The Era of AI Chatbots. Encyclopedia 2026;6(2):32 View
  10. Roca P, Zangri R, Rodriguez-Fernandez G, Sanchez-Pedreño M, García del Valle E. Artificial intelligence in the psychologist’s toolkit: Psypilot as a case study. Frontiers in Psychology 2026;17 View
  11. Chung V, Bernier P, Hudon A. Mass Media Narratives of Psychiatric Adverse Events Associated With Generative AI Chatbots: Rapid Scoping Review. JMIR Mental Health 2026;13:e93040 View
  12. Nguyen N. Suicide-Prevention Technology Toward Co-production with Caregivers. Journal of Technology in Behavioral Science 2026 View
  13. Jecker N, Ozeki-Hayashi R, Nakazawa E, Fujita T. Designing Chatbots and Social Robots for Mental Health to be Culturally Competent and People-Centered. Philosophy & Technology 2026;39(2) View
  14. Rolvien L, Kruse L, Rings S, Zimmer C, Schauenburg G, Thams F, Brähler A, Rudschies C, Schneider I, Moritz S, Steinicke F, Gallinat J. Intelligent virtual agents in psychotherapy: a safety evaluation across high-risk mental health scenarios. Scientific Reports 2026;16(1) View
  15. Schoene A, Mestre R, Middleton S, Lapedriza A, Bernard A, Lewis M, Lardizabal J, Movaghar A, Fenelon K, Lincoln A, Gaverich S, Scalise II D, Kumar G, Leeman R. Responsible AI in mental healthcare: policy directions and stakeholder insights. Frontiers in Public Health 2026;14 View
  16. Békés V, Aafjes-van Doorn K. Clinicians’ Attitudes Toward using Artificial Intelligence in Mental Health Interventions. Journal of Technology in Behavioral Science 2026 View
  17. Amaro C, Monzon A, Alderfer M, Canter K, Amylon M, Fooks-Parker S, Schleider J, Patton S, Devine K. Small but mighty: how can pediatric psychologists harness the power of digital single-session interventions?. Journal of Pediatric Psychology 2026 View
  18. Li M. Who Decides When AI Flags Risk? Professional Judgment and Boundary Work in University Psychological Crisis Intervention. International Journal of Human–Computer Interaction 2026:1 View
  19. Lindo S. AI-Related Stress and Suicidal Tendencies in a Primary Care Cohort: A Clinical Audit (Preprint). Online Journal of Public Health Informatics 2025 View

Conference Proceedings

  1. Vimal S, Harshini R, Sankari D, Srinithi D. 2025 10th International Conference on Smart Structures and Systems (ICSSS). AI-Powered Bilingual Chatbot for Promoting Mental Health Awareness in Rural Communities View
  2. Reddy J, Yasmeen , Goura K, Reddy Y, Rani K, Devi Y. 2026 5th International Conference on Innovative Practices in Technology and Management (ICIPTM). TheraMind AI: A Multilingual and Multidomain Diagnostic Assistant for Psychotherapy View
  3. Jiang Z, Chen Q, Zhang C, Li Y, LC R. Proceedings of the 2026 CHI Conference on Human Factors in Computing Systems. Hear You in Silence: Designing for Active Listening in Human Interaction with Conversational Agents Using Context-Aware Pacing View
  4. Anvari S, Ppali S, Garcia Hernandez D, Wehbe R. Proceedings of the 2026 CHI Conference on Human Factors in Computing Systems. When Your Therapist Is an Algorithm: Understanding the Role of AI in Mental Health Mobile Applications View