Accessibility settings

Published on in Vol 13 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/99185, first published .
Nurse holding patient's hands for comfort and support during medical care.

Interpretable Topic Modeling of Spontaneous Speech in Depression Using Large Language Models: Multilingual Four-Cohort Study

Interpretable Topic Modeling of Spontaneous Speech in Depression Using Large Language Models: Multilingual Four-Cohort Study

Gustave Cortal   1 , PhD ;   Sélim Benjamin Guessoum   1, 2 , MD, PhD ;   Xuan-Nga Cao   1 , PhD ;   Santiago de Leon-Martinez   3, 4 , PhD ;   Enrique Baca-García   5, 6, 7, 8, 9, 10, 11 , MD, PhD ;   Rachid Riad   1 , PhD

1 Callyope, Paris, France

2 Université Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations, Villejuif, France

3 Brno University of Technology, Brno, Czech Republic

4 Kempelen Institute of Intelligent Technologies, Bratislava, Slovakia

5 Department of Psychiatry, Hospital Universitario Fundación Jiménez Díaz, Madrid, Madrid, Spain

6 Department of Psychiatry, University Hospital Rey Juan Carlos, Mostoles, Spain

7 Department of Psychiatry, Hospital Universitario General de Villalba, Madrid, Madrid, Spain

8 Department of Psychiatry, University Hospital Infanta Elena, Valdemoro, Spain

9 Department of Psychology, Catholic University of the Maule, Talca, Maule Region, Chile

10 Department of Psychiatry, Universidad Autónoma de Madrid, Madrid, Madrid, Spain

11 Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Madrid, Spain

Corresponding Author:

  • Rachid Riad, PhD
  • Callyope
  • Pépinière d'entreprises Paris Santé Cochin, 29 Rue du Faubourg Saint-Jacques
  • Paris 75014
  • France
  • Phone: 33 0666522141
  • Email: rachid@callyope.com