Electronic Health Record–Based Phenotyping for Obsessive-Compulsive Disorder: Algorithm Development and Multicenter Validation Study

Bo Wang   ^{1, 2, 3} , PhD ;   Tyne W Miller-Fleming   ^{4, 5} , PhD ;   Dongmei Yu   ^{1, 2} , PhD ;   Donald Hucks   ⁵ , MS ;   Emily Gantz   ⁵ , DO ;   Rebecca Johnston   ⁵ , MS ;   Angela Maxwell-Horn   ⁵ , MD ;   Nancy Cox   ⁵ , PhD ;   James Sutcliffe   ⁴ , PhD ;   Carol A Mathews   ⁶ , MD ;   Evonne McArthur   ⁵ , MD, PhD ;   Patrick L McGuire   ^{3, 7} , MD ;   Dia Kabir   ¹ , MS ;   Ashley Dankese   ¹ ;   Evan J Giangrande   ^{1, 2, 3} , PhD ;   Rebecca G Fortgang   ^{1, 3} , PhD ;   Shirley B Wang   ⁸ , PhD ;   Rakesh Karmacharya   ^{1, 2, 3} , MD, PhD ;   Joshua L Roffman   ^{1, 3} , MD ;   Jeremiah M Scharf   ^{1, 2} , MD, PhD ;   Jordan W Smoller   ^{1, 2, 3} , MD, SCD ;   Takahiro Soda   ^{6, 9, 10} , MD, PhD ;   James J Crowley   ¹¹ , PhD ;   Lea K Davis   ^{5, 12, 13} , PhD

¹ Massachusetts General Hospital, Boston, MA, United States

² Broad Institute of MIT and Harvard, Boston, MA, United States

³ Department of Psychiatry, Harvard Medical School, Boston, MA, United States

⁴ Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, United States

⁵ Vanderbilt University Medical Center, Nashville, TN, United States

⁶ Department of Psychiatry, University of Florida, Gainesville, FL, United States

⁷ Brigham and Women's Faulkner Hospital, Boston, MA, United States

⁸ Department of Psychology, Yale University, New Haven, CT, United States

⁹ University of Florida Genetics Institute, Gainesville, FL, United States

¹⁰ Center for Autism and Neurodevelopment, University of Florida, Gainesvilles, FL, United States

¹¹ Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

¹² Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States

¹³ New York Genome Center, New York, NY, United States