Theme Issue 2025: AI-Powered Therapy Bots and Virtual Companions in Digital Mental Health

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Years in this theme: All years 2026 2025

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Articles published in 2026 in this theme: 10 (scroll down to load remaining articles)

2026

Laptop screen shows a mind map of mental wellness concepts like anxiety, depression, and resilience.

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Frameworks, Methodologies, and Tools for Evaluating Large Language Models in Digital Mental Health Interventions: Protocol for a Scoping Review

Antonio Salinas-Layana, Álvaro Jiménez-Molina, Daniela Lira, Félix Alberto Véliz-Montoya, Alexi Venegas, Nicolás Muñoz, Mario Chandía, Rigoberto Rojas, Vania Martínez

JMIR Res Protoc 2026 (Sep 14); 15:e91677

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AI bridging gap between technology and healthcare, with people walking towards a hospital.

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When Markets Shape AI Mental Health Self-Management Tools: Consequences for Serious Mental Illness

Lucy Smith, Yousef Yousef, Piotr Wasilewski, Hajira Dambha-Miller

JMIR Ment Health 2026 (Aug 25); 13:e99143

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Elderly man using a tablet with a search bar overlay.

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Personalized Intelligent Chatbot Based on AI-Generated Content Assists Memoir Writing for Older Adults With Cognitive Impairment: Mixed Methods Study

Yibo Meng, Yuan Que, Zhe Yan, Bingyi Liu, Zixin Wang, Mandi Yang, Huidi Lu

JMIR Hum Factors 2026 (Aug 25); 13:e83428

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Young man with glasses looking at his smartphone

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Generative AI in Youth Mental Health Apps: Rapid Review

Helene Høgsdal, Henriette Kyrrestad, Sabine Kaiser

JMIR Ment Health 2026 (Aug 19); 13:e90589

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AI-Related Stress and Suicidal Tendencies in a Primary Care Cohort: Clinical Audit

Shemarah Lindo

Online J Public Health Inform 2026 (Jul 29); 18:e84661

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Man in plaid shirt using smartphone at outdoor table with whiskey drink

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User Perspectives on Conversational Agents for Preventive Alcohol Self-Help: Qualitative Exploratory Study

Marissa De Vries, Melissa Begeman, Marloes Derksen, Anna Goudriaan, Matthijs Blankers

JMIR Hum Factors 2026 (Jul 14); 13:e86752

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Woman on a video call with a smiling blonde woman on a smartphone.

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Effectiveness of a Fully Automated Mobile Therapeutic Versus a General Chatbot in Reducing Depression and Anxiety and Improving Well-Being: Feasibility Randomized Controlled Trial

Barbora Kuta, Lukas Novak, Radka Zidkova, Jana Furstova, Klara Malinakova, Andrea De Winter, Vít Husek

JMIR Ment Health 2026 (Apr 22); 13:e82642

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Person using a mindfulness app on a smartphone for stress relief

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User Experience and Early Clinical Outcomes of a Mental Wellness Chatbot for Depression and Anxiety: Pilot Evaluation Mixed Methods Study

Scott Graupensperger, Emily J Ward, Graham Baum, Kate H Bentley, Emily R Dworkin, Millard Brown, Adam Chekroud, Matt Hawrilenko

JMIR Form Res 2026 (Apr 14); 10:e90644

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Woman texting on smartphone while relaxing on couch

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AI Chatbots for Mental Health Self-Management: Lived Experience–Centered Qualitative Study

Dong Whi Yoo, Jiayue Melissa Shi, Violeta J Rodriguez, Koustuv Saha

JMIR Ment Health 2026 (Apr 02); 13:e78288

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iPhone displaying a mental wellness app with a chatbot named Ebb

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Real-World Use of a Mental Health AI Companion: Multiple Methods Study

Christine Callahan, Leah Tanner, Chelsea Coe, Michelle Davis, Jenna Glover, Ellis Bernstein, Katherine Scranton, Kenli Urruty, Matthew Chester, Sarah Kunkle

JMIR Form Res 2026 (Feb 13); 10:e86904

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