The Effect of Bipolar Disorder Illness Course on Physiological Digital Signals: Observational Study

Clàudia Valenzuela-Pascual   ^{1, 2, 3, 4} , MSc ;   Marina Garriga   ^{1, 2, 3, 4 *} , MD, PhD ;   Roger Borràs   ^{1, 3} , MSc ;   Ruth Voltà-Solerdelcoll   ^{1, 2, 3, 4} , MSc ;   Marta Korniyenko   ^{1, 2, 3, 4} , MSc ;   Ariadna Mas   ^{1, 2, 3, 4} , MSc ;   Clara Escala   ^{1, 2, 3, 4} , MSc ;   Peter De Looff   ^{5, 6, 7, 8} , PhD ;   Gerard Anmella   ^{1, 2, 3, 4} , MD, PhD ;   Antonio Benabarre   ^{1, 2, 3, 4} , MD, PhD ;   Isabella Pacchiarotti   ^{1, 2, 3, 4} , MD, PhD ;   Anna Bastidas   ¹ , RN ;   Isabel Agasi   ¹ , RN ;   Meritxell González-Campos   ^{1, 2, 3, 4} , MD, PhD ;   Iria Grande   ^{1, 2, 3, 4} , MD, PhD ;   Cristina Romero-López-Alberca   ^{3, 9} , PhD ;   Cecilia Muñoz-Doña   ⁹ , MSc ;   Ana Catalan   ^{3, 10} , MD, PhD ;   Esteban Sepulveda   ^{3, 11, 12, 13} , MD, PhD ;   Eduard Vieta   ^{1, 2, 3, 4} , MD, PhD ;   Marc Valentí   ^{1, 2, 3, 4 *} , MD, PhD ;   Diego Hidalgo-Mazzei   ^{1, 2, 3, 4 *} , MD, PhD

¹ Department of Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain

² Bipolar and Depressive Disorders Unit, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain

³ Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain

⁴ Department of Medicine, School of Medicine and Health Sciences, Institute of Neurosciences (UBNeuro), University of Barcelona (UB), Barcelona, Catalonia, Spain

⁵ Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, Gelderland, The Netherlands

⁶ Fivoor, Science and Treatment Innovation, Rotterdam, The Netherlands

⁷ Department of Developmental Psychology, Tilburg University, Tilburg, The Netherlands

⁸ Specialized Forensic Care, De Borg National Expert Center, Den Dolder, The Netherlands

⁹ Department of Psychology, University of Cádiz, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cadiz, Andalusia, Spain

¹⁰ Department of Neuroscience, Biobizkaia Health Research Institute, Basque Country University, Basurto University Hospital, OSI Bilbao-Basurto, Barakaldo, Bizkaia, Spain

¹¹ Hospital Psiquiàtric Universitari Institut Pere Mata, Reus, Spain

¹² Rovira i Virgili University, Reus, Spain

¹³ Institut Investigació Sanitària Pere Virgili, CERCA, Reus, Spain

*these authors contributed equally