An App-Based Digit Symbol Substitution Test for Assessment of Cognitive Deficits in Adults With Major Depressive Disorder: Evaluation Study

Roger S McIntyre   ^{1, 2, 3, 4} , MD ;   Orly Lipsitz   ^{1, 4} , BScH ;   Nelson B Rodrigues   ^{1, 4} , MSc ;   Mehala Subramaniapillai   ^{1, 4} , MSc ;   Flora Nasri   ⁴ , MSc ;   Yena Lee   ¹ , PhD ;   Ben Fehnert   ^{5, 6} , MA ;   James King   ⁶ , MA ;   Lambros Chrones   ⁷ , MD ;   Kevin Kratiuk   ⁴ , PharmD ;   Sharif Uddin   ⁷ , MS ;   Joshua D Rosenblat   ^{1, 2, 3, 4} , MD ;   Rodrigo B Mansur   ^{1, 3} , MD ;   Maggie McCue   ⁷ , MS, RD

¹ University Health Network, Mood Disorders Psychopharmacology Unit, Toronto, ON, Canada

² Brain and Cognition Discovery Foundation, Toronto, ON, Canada

³ Department of Psychiatry, University of Toronto, Toronto, ON, Canada

⁴ Canadian Rapid Treatment Center of Excellence, Mississauga, ON, Canada

⁵ Ctrl Group, London, United Kingdom

⁶ Cognition Kit, Cambridge, United Kingdom

⁷ Takeda Pharmaceuticals U.S.A., Inc., Lexington, MA, United States