Published on in Vol 6, No 10 (2019): October

Preprints (earlier versions) of this paper are available at, first published .
Conversational Agents in the Treatment of Mental Health Problems: Mixed-Method Systematic Review

Conversational Agents in the Treatment of Mental Health Problems: Mixed-Method Systematic Review

Conversational Agents in the Treatment of Mental Health Problems: Mixed-Method Systematic Review

Authors of this article:

Hannah Gaffney 1 Author Orcid Image ;   Warren Mansell 1 Author Orcid Image ;   Sara Tai 1 Author Orcid Image


  1. Robinson N, Connolly J, Hides L, Kavanagh D. Social robots as treatment agents: Pilot randomized controlled trial to deliver a behavior change intervention. Internet Interventions 2020;21:100320 View
  2. Almohanna A, Win K, Meedya S. Effectiveness of Internet-Based Electronic Technology Interventions on Breastfeeding Outcomes: Systematic Review. Journal of Medical Internet Research 2020;22(5):e17361 View
  3. Chew A, Ong R, Lei H, Rajendram M, K V G, Verma S, Fung D, Leong J, Gunasekeran D. Digital Health Solutions for Mental Health Disorders During COVID-19. Frontiers in Psychiatry 2020;11 View
  4. Baptista S, Wadley G, Bird D, Oldenburg B, Speight J. Acceptability of an Embodied Conversational Agent for Type 2 Diabetes Self-Management Education and Support via a Smartphone App: Mixed Methods Study. JMIR mHealth and uHealth 2020;8(7):e17038 View
  5. Bickman L. Improving Mental Health Services: A 50-Year Journey from Randomized Experiments to Artificial Intelligence and Precision Mental Health. Administration and Policy in Mental Health and Mental Health Services Research 2020;47(5):795 View
  6. Zhang M, Smith H. Digital Tools to Ameliorate Psychological Symptoms Associated With COVID-19: Scoping Review. Journal of Medical Internet Research 2020;22(8):e19706 View
  7. Gaffney H, Mansell W, Tai S. Agents of change: Understanding the therapeutic processes associated with the helpfulness of therapy for mental health problems with relational agent MYLO. DIGITAL HEALTH 2020;6:205520762091158 View
  8. Chattopadhyay D, Ma T, Sharifi H, Martyn-Nemeth P. Computer-Controlled Virtual Humans in Patient-Facing Systems: Systematic Review and Meta-Analysis. Journal of Medical Internet Research 2020;22(7):e18839 View
  9. Davis C, Murphy K, Curtis R, Maher C. A Process Evaluation Examining the Performance, Adherence, and Acceptability of a Physical Activity and Diet Artificial Intelligence Virtual Health Assistant. International Journal of Environmental Research and Public Health 2020;17(23):9137 View
  10. Vaidyam A, Linggonegoro D, Torous J. Changes to the Psychiatric Chatbot Landscape: A Systematic Review of Conversational Agents in Serious Mental Illness: Changements du paysage psychiatrique des chatbots: une revue systématique des agents conversationnels dans la maladie mentale sérieuse. The Canadian Journal of Psychiatry 2021;66(4):339 View
  11. Prochaska J, Vogel E, Chieng A, Kendra M, Baiocchi M, Pajarito S, Robinson A. A Therapeutic Relational Agent for Reducing Problematic Substance Use (Woebot): Development and Usability Study. Journal of Medical Internet Research 2021;23(3):e24850 View
  12. Daley K, Hungerbuehler I, Cavanagh K, Claro H, Swinton P, Kapps M. Preliminary Evaluation of the Engagement and Effectiveness of a Mental Health Chatbot. Frontiers in Digital Health 2020;2 View
  13. Koman J, Fauvelle K, Schuck S, Texier N, Mebarki A. Physicians’ Perceptions of the Use of a Chatbot for Information Seeking: Qualitative Study. Journal of Medical Internet Research 2020;22(11):e15185 View
  14. Richardson C, Slemon A, Gadermann A, McAuliffe C, Thomson K, Daly Z, Salway T, Currie L, David A, Jenkins E. Use of Asynchronous Virtual Mental Health Resources for COVID-19 Pandemic–Related Stress Among the General Population in Canada: Cross-Sectional Survey Study. Journal of Medical Internet Research 2020;22(12):e24868 View
  15. Sanatkar S, Baldwin P, Huckvale K, Christensen H, Harvey S. e-Mental Health Program Usage Patterns in Randomized Controlled Trials and in the General Public to Inform External Validity Considerations: Sample Groupings Using Cluster Analyses. Journal of Medical Internet Research 2021;23(3):e18348 View
  16. Jang S, Kim J, Kim S, Hong J, Kim S, Kim E. Mobile app-based chatbot to deliver cognitive behavioral therapy and psychoeducation for adults with attention deficit: A development and feasibility/usability study. International Journal of Medical Informatics 2021;150:104440 View
  17. Gabrielli S, Rizzi S, Bassi G, Carbone S, Maimone R, Marchesoni M, Forti S. Engagement and Effectiveness of a Healthy-Coping Intervention via Chatbot for University Students During the COVID-19 Pandemic: Mixed Methods Proof-of-Concept Study. JMIR mHealth and uHealth 2021;9(5):e27965 View
  18. Kolenik T, Gams M. Intelligent Cognitive Assistants for Attitude and Behavior Change Support in Mental Health: State-of-the-Art Technical Review. Electronics 2021;10(11):1250 View
  19. Klos M, Escoredo M, Joerin A, Lemos V, Rauws M, Bunge E. Artificial Intelligence–Based Chatbot for Anxiety and Depression in University Students: Pilot Randomized Controlled Trial. JMIR Formative Research 2021;5(8):e20678 View
  20. Hocking J, Oster C, Maeder A. Use of conversational agents in rehabilitation following brain injury, disease, or stroke: a scoping review protocol. JBI Evidence Synthesis 2021;19(6):1369 View
  21. Kocur M, Dechant M, Wolff C, Nothdurfter C, Wetter T, Rupprecht R, Shiban Y. Computer-Assisted Avatar-Based Treatment for Dysfunctional Beliefs in Depressive Inpatients: A Pilot Study. Frontiers in Psychiatry 2021;12 View
  22. Mauriello M, Tantivasadakarn N, Mora-Mendoza M, Lincoln E, Hon G, Nowruzi P, Simon D, Hansen L, Goenawan N, Kim J, Gowda N, Jurafsky D, Paredes P. Popbots—A Suite of Mobile Conversational Agents for Daily Stress Management: A Mixed Methods Exploratory Study (Preprint). JMIR Formative Research 2020 View

Books/Policy Documents

  1. Hudlicka E. Augmented Cognition. Human Cognition and Behavior. View