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Enhancing Adherence to Continuous Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea Using Augmented Reality: Protocol for a Randomized Controlled Trial

Enhancing Adherence to Continuous Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea Using Augmented Reality: Protocol for a Randomized Controlled Trial

Data from CPAP devices (eg, Air Sense 10 Auto Set) will be collected at T1, T2, and T3, tracking the percentage of nights meeting adherence criteria. Adherence refers to the patient’s adherence to CPAP therapy, which means using CPAP for more than 70% of the total sleep time during the night, with a minimum duration of 4 hours.

Ming-Che Chen, Yen-Chin Chen, Cheng-Yu Lin

JMIR Res Protoc 2025;14:e69757

Adapting a Text Messaging Intervention to Improve Diabetes Medication Adherence in a Spanish-Speaking Population: Qualitative Study

Adapting a Text Messaging Intervention to Improve Diabetes Medication Adherence in a Spanish-Speaking Population: Qualitative Study

While interventions that address patient-reported barriers to diabetes medication adherence can improve glycemic management [20,21], interventions that address barriers to diabetes medication adherence of relevance to Latino adults with T2 D are lacking.

Jacqueline Seiglie, Seth Tobolsky, Ricaurte Crespo Trevino, Lluvia Cordova, Sara Cromer, A Enrique Caballero, Margarita Alegria, J Jaime Miranda, Deborah Wexler, Lindsay Mayberry

JMIR Hum Factors 2025;12:e66668

Integration of a Mental Health App (e-MICHI) Into a Blended Treatment of Depression in Adolescents: Single-Group, Naturalistic Feasibility Trial

Integration of a Mental Health App (e-MICHI) Into a Blended Treatment of Depression in Adolescents: Single-Group, Naturalistic Feasibility Trial

Numerous studies have reported high dropout rates and low adherence levels for nonguided e-health interventions [9,10]. DHIs that include some form of personalized support, for example, from psychotherapeutic professionals, seem to be more efficacious due to higher adherence rates [11]. In addition to adherence, transferability presents a further challenge.

Lena Lincke, Tim Martin-Döring, Andrea Daunke, Antonia Sadkowiak, Daria Alexandra Nolkemper, Nina Sproeber-Kolb, Stefanie Bienioschek, Olaf Reis, Michael Kölch

JMIR Form Res 2025;9:e58427

Centering Youth Voice in the Adaptation of an mHealth Intervention for Young Adults With HIV in South Texas, United States: Human-Centered Design Approach

Centering Youth Voice in the Adaptation of an mHealth Intervention for Young Adults With HIV in South Texas, United States: Human-Centered Design Approach

The platform includes daily medication adherence tracking, mood and stress self-assessment, appointment reminders, secure messaging with clinic providers, and an anonymous online peer support network [25]. We used human-centered design thinking processes in this adaptation to ensure young adults with HIV input, as interventions are more effective when impacted communities are involved in their design and implementation [5].

Nhat Minh Ho, Catherine Johnson, Autumn Chidester, Ruby Viera Corral, Jacundo Ramos, Miguel Garcia, Rishi Gonuguntla, Cyrena Cote, Divya Chandramohan, Hueylie Lin, Anna Taranova, Ank E Nijhawan, Susan Kools, Karen Ingersoll, Rebecca Dillingham, Barbara S Taylor

JMIR Form Res 2025;9:e60531

Clinical, Psychological, Physiological, and Technical Parameters and Their Relationship With Digital Tool Use During Cardiac Rehabilitation: Comparison and Correlation Study

Clinical, Psychological, Physiological, and Technical Parameters and Their Relationship With Digital Tool Use During Cardiac Rehabilitation: Comparison and Correlation Study

Patients were asked to answer 17 questions concerning their adherence to cardiac rehabilitation, which were based on the Exercise Adherence Rating Scale (EARS) [25]. Eleven out of the 17 questions concerned reasons for nonadherence, while the remaining 6 questions focused on adherence. EARS was translated to German and slightly adapted according to the study needs (refer to the self-reported adherence to the exercise program section for the detailed questions).

Fabian Wiesmüller, David Haag, Mahdi Sareban, Karl Mayr, Norbert Mürzl, Michael Porodko, Christoph Puelacher, Lisa-Marie Moser, Marco Philippi, Heimo Traninger, Stefan Höfer, Josef Niebauer, Günter Schreier, Dieter Hayn

JMIR Mhealth Uhealth 2025;13:e57413

Determining the Prioritization of Behavior Change Techniques for Long-Term Stroke Rehabilitation: Delphi Survey Study

Determining the Prioritization of Behavior Change Techniques for Long-Term Stroke Rehabilitation: Delphi Survey Study

This uncovers a gap between current stroke rehabilitation practice and the potential of BCTs, as it leaves critical questions as to which BCTs should be prioritized when supporting the long-term treatment adherence required. Further, this reinforces the relevance and urgency of addressing long-term behavior change and treatment adherence specifically for stroke rehabilitation.

Agata Ewa Wróbel, Philip Cash, Anja Maier, John Paulin Hansen

Interact J Med Res 2025;14:e59172

Participant Adherence in Repeated-Dose Clinical Studies Using Video-Based Observation: Retrospective Data Analysis

Participant Adherence in Repeated-Dose Clinical Studies Using Video-Based Observation: Retrospective Data Analysis

In all cohorts, high adherence was mandatory to achieve the study objectives, and participants provided informed consent before participation. This is likely the primary reason for the relatively high adherence observed across cohorts compared with that observed in later clinical trials or real-world settings [5,26]. Nevertheless, the clear benefits of using a VSMS were consistent with previous studies of similar systems [16-18,20-25,27-30].

Seunghoon Han, Jihong Song, Sungpil Han, Suein Choi, Jonghyuk Lim, Byeong Yeob Oh, Dongoh Shin

JMIR Mhealth Uhealth 2025;13:e65668

Evaluation of the Tu’Washindi Na PrEP Intervention to Reduce Gender-Based Violence and Increase Preexposure Prophylaxis Uptake and Adherence Among Kenyan Adolescent Girls and Young Women: Protocol for a Cluster Randomized Controlled Trial

Evaluation of the Tu’Washindi Na PrEP Intervention to Reduce Gender-Based Violence and Increase Preexposure Prophylaxis Uptake and Adherence Among Kenyan Adolescent Girls and Young Women: Protocol for a Cluster Randomized Controlled Trial

Studies have found that IPV and other partner-related social harms are associated with 1.5- to 2.5-fold higher risk of poor adherence to oral Pr EP and the dapivirine ring for HIV prevention. Similar to HIV treatment and contraception [19,20,24-29], IPV and relationship inequality introduce barriers to uptake of and adherence to Pr EP at multiple levels.

Sarah T Roberts, Alexandra M Minnis, Sue Napierala, Elizabeth T Montgomery, Lina Digolo, Mackenzie L Cottrell, Erica N Browne, Jacqueline Ndirangu, Joyce Boke, Kawango Agot

JMIR Res Protoc 2025;14:e55931

Barriers and Determinants of Referral Adherence in AI-Enabled Diabetic Retinopathy Screening for Older Adults in Northern India During the COVID-19 Pandemic: Mixed Methods Pilot Study

Barriers and Determinants of Referral Adherence in AI-Enabled Diabetic Retinopathy Screening for Older Adults in Northern India During the COVID-19 Pandemic: Mixed Methods Pilot Study

Limited research exists in India on older adults’ adherence to DRS referral recommendations and the barriers influencing their decisions. This study aims to (1) evaluate the referral adherence rates among older adult participants after AI-enabled DRS and identify the key factors affecting adherence during the COVID-19 pandemic and (2) identify and analyze the barriers to adherence to referral recommendations during the COVID-19 pandemic. The overall study design is described in Figure 1.

Anshul Chauhan, Anju Goyal, Ritika Masih, Gagandeep Kaur, Lakshay Kumar, ­ Neha, Harsh Rastogi, Sonam Kumar, Bidhi Lord Singh, Preeti Syal, Vishali Gupta, Luke Vale, Mona Duggal

JMIR Form Res 2025;9:e67047

Impact of Platform Design and Usability on Adherence and Retention: Randomized Web- and Mobile-Based Longitudinal Study

Impact of Platform Design and Usability on Adherence and Retention: Randomized Web- and Mobile-Based Longitudinal Study

Clinical trial retention and adherence rates vary greatly across and within therapeutic areas [1-3]. Low adherence and retention increase costs and negatively impact data quality and the validity of research findings. Mitigating the various retention and adherence challenges in clinical trials is a major focus of clinical trial sponsors and researchers [4]. Studies can improve retention by strategically recruiting individuals or populations more likely to complete a trial [1].

Xinrui Jiang, Michelle Timmons, Elias Boroda, Marie Onakomaiya

J Particip Med 2025;17:e50225