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Skip search results from other journals and go to results- 48 Journal of Medical Internet Research
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Using historical recruitment data from our community-based study of SJS/TEN survivors, we compared data both before and after implementation of social media and web-based recruitment methods. We recruited SJS/TEN survivors from the United States, aged 7-90 years, to participate in a remote study to assess genetic risk and long-term outcomes in SJS/TEN. Survivors across the United States, who saw or heard about our study, filled out an online interest survey.
J Med Internet Res 2025;27:e63712
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A variety of barriers to successful employment outcomes for adults with autism have been identified at each stage of the recruitment and employment experience, including conventional hiring processes that are unsuited to candidates with autism, limited promotion of and requests for workplace accommodations, and a lack of employment-related and mental health supports [5,11,12].
JMIR Res Protoc 2025;14:e60806
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However, these venue-based recruitment methods may introduce selection bias as certain racial or ethnic minorities and women may feel less comfortable in and around these spaces [6-10].
Internet-based recruitment may provide an alternative method for accessing certain hard-to-reach populations and stigmatized behaviors. The primary barrier to feasibility in internet-based recruitment is access to people who use opioids, given the highly stigmatized nature of drug use [4,5].
J Med Internet Res 2025;27:e63687
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Recruitment for the BUMP study was primarily conducted via 2 methods: genetic testing service subscriber recruitment (Sema4) and 4 Youand Me direct recruitment. Genetic testing service subscriber recruitment includes outreach to subscribers to genetic testing via Sema4’s patient portal. 4 Youand Me direct recruitment consists of 3 recruitment suboutlets: social media (including both paid and unpaid outreach), community partnerships, and others (eg, word of mouth, press, and Clinical Trials.gov; Figure 1).
JMIR Form Res 2025;9:e68093
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Approximately, 25% of clinical trials are discontinued before completion [3], with insufficient recruitment being the most frequent reason in 31% of the cases [4]. For adult cancer trials, between 20% and 50% fail to complete or were unable to reach recruitment goals [5-9]. This has been exacerbated by the recent pandemic where many trials experienced a considerable reduction in recruitment rates [10-13], which has continued after the pandemic [12].
J Med Internet Res 2025;27:e66821
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Although research organizations have passively disseminated clinical trial–related content on social media platforms, this very active and intentional campaign to engage with the public is promising as it relates to clinical trial recruitment and illustrates the utility of using engaging digital content coupled with social media marketing as an effective strategy for clinical trial recruitment.
JMIR Cancer 2025;11:e56098
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If the recruitment goal of 80 participants is not met after exhausting the initial participant list, the research team will directly contact potential participants via phone calls. In addition, we will implement a social media recruitment strategy by posting study advertisements on platforms such as Facebook (Meta), Instagram (Meta), or X (formerly Twitter).
JMIR Res Protoc 2025;14:e60527
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Given the relatively large scale of our digitally mediated recruitment methods, the low risk involved in study participation, considerable financial compensation, and robust practices for ultimately verifying participants’ identity, this study provided unique insight into how deceptive practices may be occurring in large, remotely delivered behavioral studies, as well as how to mitigate their impact.
J Med Internet Res 2025;27:e66384
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Recruiting Young People for Digital Mental Health Research: Lessons From an AI-Driven Adaptive Trial
However, compared to traditional randomized controlled trials (RCTs), AI-adaptive trials face an increased risk of insufficient and untimely enrollment due to the need for frequent, short-spanned recruitment drives (eg, monthly recruitment drives over a year). Hence, identifying recruitment methodologies that are both cost-effective and time-efficient is crucial for the success of such trials.
What recruitment methods are currently used and how do they compare with each other?
J Med Internet Res 2025;27:e60413
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Gay, bisexual, and other men who have sex with men have previously been referred to as a “hard-to-reach” or “hidden” population for study recruitment [12,13], and traditional recruitment approaches for this community often included snowball sampling, use of “gatekeeper” organizations associated with the community, and venue-based recruitment at community events, health clinics, or other settings [11,14,15].
J Med Internet Res 2025;27:e64668
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