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Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial

Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial

(D) IUH: negative 5-Cog result. At both sites, a paper token (Figure 4) is used as an additional feature to help ensure that care providers review the patients’ 5-Cog results. Patients are handed this token after they complete the 5-Cog battery and are asked to hand it to their care provider at their scheduled visit, generally within 30 minutes after the 5-Cog battery administration. Token to alert care provider for patient's 5-Cog participation.

Rachel Beth Rosansky Chalmer, Emmeline Ayers, Erica F Weiss, Nicole R Fowler, Andrew Telzak, Diana Summanwar, Jessica Zwerling, Cuiling Wang, Huiping Xu, Richard J Holden, Kevin Fiori, Dustin D French, Celeste Nsubayi, Asif Ansari, Paul Dexter, Anna Higbie, Pratibha Yadav, James M Walker, Harrshavasan Congivaram, Dristi Adhikari, Mairim Melecio-Vazquez, Malaz Boustani, Joe Verghese

JMIR Res Protoc 2025;14:e60471

Considering Theory-Based Gamification in the Co-Design and Development of a Virtual Reality Cognitive Remediation Intervention for Depression (bWell-D): Mixed Methods Study

Considering Theory-Based Gamification in the Co-Design and Development of a Virtual Reality Cognitive Remediation Intervention for Depression (bWell-D): Mixed Methods Study

In one of these collaborations, with the University of British Columbia, we customized b Well to deficits observed in depression as b Well-D, a prototype of immersive VR cognitive remediation for MDD. b Well-D targets cognitive and real-world challenges germane to MDD depression [6]. It uses previously identified common components of successful cognitive remediation in psychiatric populations [42].

Mark Hewko, Vincent Gagnon Shaigetz, Michael S Smith, Elicia Kohlenberg, Pooria Ahmadi, Maria Elena Hernandez Hernandez, Catherine Proulx, Anne Cabral, Melanie Segado, Trisha Chakrabarty, Nusrat Choudhury

JMIR Serious Games 2025;13:e59514

Limitations of Binary Classification for Long-Horizon Diagnosis Prediction and Advantages of a Discrete-Time Time-to-Event Approach: Empirical Analysis

Limitations of Binary Classification for Long-Horizon Diagnosis Prediction and Advantages of a Discrete-Time Time-to-Event Approach: Empirical Analysis

Each observation was represented by the triplet {X,T,S}, where X⊆Rd is a d-dimensional feature vector, T∈(0,Emax] is an observed event or censoring time over a finite time horizon, and S∈{0,1} indicates whether T is a right-censoring time (S=0) or an event time (S=1). The observed time T is the minimum of the event time E and the right-censoring time C, that is, T=min(E, C).

De Rong Loh, Elliot D Hill, Nan Liu, Geraldine Dawson, Matthew M Engelhard

JMIR AI 2025;4:e62985

Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomized Controlled Trial

Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomized Controlled Trial

At the 30-second mark of the third math trial, the data collector will use an automatic BP machine (clinician grade) to measure systolic BP, diastolic BP, and heart rate. CN is a neuropsychologist who will assist in the interpretation of data. The Pittsburgh Stress Battery was identified as a valid measure of stress reactivity by the Science of Behavior Change Research Network [48].

Kathy D Wright, Ingrid K Richards Adams, Nathan P Helsabeck, Karen M Rose, Karen O Moss, Donya Nemati, Navia Palmer, Bohyun Kim, Sunita Pokhrel Bhattarai, Christopher Nguyen, Daniel Addison, Maryanna D Klatt

JMIR Res Protoc 2025;14:e66975

Theory-Based Social Media Intervention for Nonmedical Use of Prescription Opioids in Young Adults: Protocol for a Randomized Controlled Trial

Theory-Based Social Media Intervention for Nonmedical Use of Prescription Opioids in Young Adults: Protocol for a Randomized Controlled Trial

In terms of the aim for the preliminary efficacy evaluation (ie, secondary outcomes of psychosocial and behavioral factors associated with NMUPO), we estimate an effect size according to a previous review on digital interventions for illicit drug use [111] and found small-to-medium effect sizes (Cohen d=–0.17 to –0.34) with a 6-month follow-up assessment. G-power analysis [112] estimated a sample size of 10 to 35 per arm for an RCT (repeated measures analysis of covariance).

Cheuk Chi Tam, Sean D Young, Sayward Harrison, Xiaoming Li, Alain H Litwin

JMIR Res Protoc 2025;14:e65847

Treatment of Substance Use Disorders With a Mobile Phone App Within Rural Collaborative Care Management (Senyo Health): Protocol for a Mixed Methods Randomized Controlled Trial

Treatment of Substance Use Disorders With a Mobile Phone App Within Rural Collaborative Care Management (Senyo Health): Protocol for a Mixed Methods Randomized Controlled Trial

Panel (C) shows a behavioral activation task, and panel (D) showcases the points awarded for completing this task. Senyo Health chat feature being displayed from the perspective of the recovery coach. The left is conversations with multiple patients. Once selected, the full conversation appears in the center of the screen, with the recovery coach able to text back and forth. Surveys, modules, and activation tasks can also be assigned to the participant through the chat.

Tyler S Oesterle, Nicholas L Bormann, Margaret M Paul, Scott A Breitinger, Benjamin Lai, Jamie L Smith, Cindy J Stoppel, Stephan Arndt, Mark D Williams

JMIR Res Protoc 2025;14:e65693