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Combining Artificial Intelligence and Human Support in Mental Health: Digital Intervention With Comparable Effectiveness to Human-Delivered Care

Combining Artificial Intelligence and Human Support in Mental Health: Digital Intervention With Comparable Effectiveness to Human-Delivered Care

Clinical effectiveness was quantified by calculating the change in anxiety symptoms, measured using the GAD-7, from baseline to final score, and estimating a within-participant effect size (Cohen d). A negative mean change denotes a reduction in GAD-7 total scores. Absolute Cohen d values are presented. The threshold for a clinically meaningful reduction in symptoms was defined as a change greater than the reliable change index of the GAD-7 scale (minimum of a 4-point reduction) [54].

Clare E Palmer, Emily Marshall, Edward Millgate, Graham Warren, Michael Ewbank, Elisa Cooper, Samantha Lawes, Alastair Smith, Chris Hutchins-Joss, Jessica Young, Malika Bouazzaoui, Morad Margoum, Sandra Healey, Louise Marshall, Shaun Mehew, Ronan Cummins, Valentin Tablan, Ana Catarino, Andrew E Welchman, Andrew D Blackwell

J Med Internet Res 2025;27:e69351

The Prevalence and Incidence of Suicidal Thoughts and Behavior in a Smartphone-Delivered Treatment Trial for Body Dysmorphic Disorder: Cohort Study

The Prevalence and Incidence of Suicidal Thoughts and Behavior in a Smartphone-Delivered Treatment Trial for Body Dysmorphic Disorder: Cohort Study

people with BDD have high rates of suicidal thoughts [20,21,22,23], suicide attempts [eg, 21, 24, 25], and completed suicides [21]; (2) although the current RCT excluded based on “active” suicidal thoughts occurring in the past month, it did not exclude any form of STB occurring>30 days before baseline assessment, including past suicide attempt, active suicidal ideation, plans, and intent, which makes it less restrictive than other BDD focused DMHI trials; and (3) participants with some forms of recent (ie, ≤30 d

Adam C Jaroszewski, Natasha Bailen, Simay I Ipek, Jennifer L Greenberg, Susanne S Hoeppner, Hilary Weingarden, Ivar Snorrason, Sabine Wilhelm

JMIR Ment Health 2025;12:e63605

Cognitive Behavioral Immersion for Depression: Protocol for a Three-Arm Randomized Controlled Trial of Peer-Based Coaching in the Metaverse

Cognitive Behavioral Immersion for Depression: Protocol for a Three-Arm Randomized Controlled Trial of Peer-Based Coaching in the Metaverse

Power analyses were focused on the ability to detect a medium effect size (Cohen d=0.50) at postcondition in the context of a 2-level random coefficients HLM. Given that the primary contrast of interest would be that between CBI and the other study conditions, calculations were focused on detecting significant differences between two active conditions. Where study parameters in this 2-level model were not yet known, we used standard values and varied parameters to approximate an effective sample size.

Noah Robinson, Francisco N Ramos, Steven D Hollon, Gloria T Han, Iony D Ezawa

JMIR Res Protoc 2025;14:e65970