%0 Journal Article %@ 2368-7959 %I JMIR Publications %V 11 %N %P e49467 %T Design and Implementation of a Brief Digital Mindfulness and Compassion Training App for Health Care Professionals: Cluster Randomized Controlled Trial %A Jaiswal,Satish %A Purpura,Suzanna R %A Manchanda,James K %A Nan,Jason %A Azeez,Nihal %A Ramanathan,Dhakshin %A Mishra,Jyoti %+ Department of Psychiatry, University of California San Diego, 9452 Medical Center Dr, La Jolla, CA, San Diego, CA, 92037, United States, 1 858 232 2855, s2jaiswal@health.ucsd.edu %K compassion %K digital app %K digital health %K digital intervention %K digital mental health %K digital mindfulness %K EEG %K health workers %K healthcare professionals %K mindfulness %K neuroplasticity %K physicians %K training %D 2024 %7 22.1.2024 %9 Original Paper %J JMIR Ment Health %G English %X Background: Several studies show that intense work schedules make health care professionals particularly vulnerable to emotional exhaustion and burnout. Objective: In this scenario, promoting self-compassion and mindfulness may be beneficial for well-being. Notably, scalable, digital app–based methods may have the potential to enhance self-compassion and mindfulness in health care professionals. Methods: In this study, we designed and implemented a scalable, digital app–based, brief mindfulness and compassion training program called “WellMind” for health care professionals. A total of 22 adult participants completed up to 60 sessions of WellMind training, 5-10 minutes in duration each, over 3 months. Participants completed behavioral assessments measuring self-compassion and mindfulness at baseline (preintervention), 3 months (postintervention), and 6 months (follow-up). In order to control for practice effects on the repeat assessments and calculate effect sizes, we also studied a no-contact control group of 21 health care professionals who only completed the repeated assessments but were not provided any training. Additionally, we evaluated pre- and postintervention neural activity in core brain networks using electroencephalography source imaging as an objective neurophysiological training outcome. Results: Findings showed a post- versus preintervention increase in self-compassion (Cohen d=0.57; P=.007) and state-mindfulness (d=0.52; P=.02) only in the WellMind training group, with improvements in self-compassion sustained at follow-up (d=0.8; P=.01). Additionally, WellMind training durations correlated with the magnitude of improvement in self-compassion across human participants (ρ=0.52; P=.01). Training-related neurophysiological results revealed plasticity specific to the default mode network (DMN) that is implicated in mind-wandering and rumination, with DMN network suppression selectively observed at the postintervention time point in the WellMind group (d=–0.87; P=.03). We also found that improvement in self-compassion was directly related to the extent of DMN suppression (ρ=–0.368; P=.04). Conclusions: Overall, promising behavioral and neurophysiological findings from this first study demonstrate the benefits of brief digital mindfulness and compassion training for health care professionals and compel the scale-up of the digital intervention. Trial Registration: Trial Registration: International Standard Randomized Controlled Trial Number Registry ISRCTN94766568, https://www.isrctn.com/ISRCTN94766568 %M 38252479 %R 10.2196/49467 %U https://mental.jmir.org/2024/1/e49467 %U https://doi.org/10.2196/49467 %U http://www.ncbi.nlm.nih.gov/pubmed/38252479