@Article{info:doi/10.2196/43164,
author="Cochran, Amy
and Maronge, Jacob M
and Victory, Amanda
and Hoel, Sydney
and McInnis, Melvin G
and Thomas, Emily BK",
title="Mobile Acceptance and Commitment Therapy in Bipolar Disorder: Microrandomized Trial",
journal="JMIR Ment Health",
year="2023",
month="Apr",
day="20",
volume="10",
pages="e43164",
keywords="acceptance and commitment therapy; bipolar disorder; mobile applications; randomized controlled trials; micro-randomized trial; precision medicine; mindfulness",
abstract="Background: Mobile interventions promise to fill in gaps in care with their broad reach and flexible delivery. Objective: Our goal was to investigate delivery of a mobile version of acceptance and commitment therapy (ACT) for individuals with bipolar disorder (BP). Methods: Individuals with BP (n=30) participated in a 6-week microrandomized trial. Twice daily, participants logged symptoms in the app and were repeatedly randomized (or not) to receive an ACT intervention. Self-reported behavior and mood were measured as the energy devoted to moving toward valued domains or away from difficult emotions and with depressive d and manic m scores from the digital survey of mood in BP survey (digiBP). Results: Participants completed an average of 66{\%} of in-app assessments. Interventions did not significantly impact the average toward energy or away energy but did significantly increase the average manic score m (P=.008) and depressive score d (P=.02). This was driven by increased fidgeting and irritability and interventions focused on increasing awareness of internal experiences. Conclusions: The findings of the study do not support a larger study on the mobile ACT in BP but have significant implications for future studies seeking mobile therapy for individuals with BP. Trial Registration: ClinicalTrials.gov NCT04098497; https://clinicaltrials.gov/ct2/show/NCT04098497 ",
issn="2368-7959",
doi="10.2196/43164",
url="https://mental.jmir.org/2023/1/e43164",
url="https://doi.org/10.2196/43164",
url="http://www.ncbi.nlm.nih.gov/pubmed/37079363"
}