<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="review-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Ment Health</journal-id><journal-id journal-id-type="publisher-id">mental</journal-id><journal-id journal-id-type="index">16</journal-id><journal-title>JMIR Mental Health</journal-title><abbrev-journal-title>JMIR Ment Health</abbrev-journal-title><issn pub-type="epub">2368-7959</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v12i1e66950</article-id><article-id pub-id-type="doi">10.2196/66950</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Factors Associated With Digital Addiction: Umbrella Review</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Han</surname><given-names>Yun</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Qiu</surname><given-names>Jiamin</given-names></name><degrees>BBA</degrees><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Shi</surname><given-names>Chengbin</given-names></name><degrees>BBA</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Huang</surname><given-names>Shiqi</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Huang</surname><given-names>Haokun</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Wang</surname><given-names>Xinman</given-names></name><degrees>UG</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Zhu</surname><given-names>Sui</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Lu</surname><given-names>Da-lin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Lu</surname><given-names>Peng</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" corresp="yes" equal-contrib="yes"><name name-style="western"><surname>Zeng</surname><given-names>Fangfang</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib></contrib-group><aff id="aff1"><institution>School of Marxism, Huaqiao University</institution><addr-line>Xiamen</addr-line><country>China</country></aff><aff id="aff2"><institution>Department of Public Health and Preventive Medicine, School of Medicine, Jinan University</institution><addr-line>No. 601, Huangpu Avenue West, Tianhe District</addr-line><addr-line>Guangzhou</addr-line><country>China</country></aff><aff id="aff3"><institution>Chinese Language and Culture College, Huaqiao University</institution><addr-line>Xiamen</addr-line><country>China</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Torous</surname><given-names>John</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>G&#x00FC;rkan</surname><given-names>Dilek Y&#x0131;ld&#x0131;r&#x0131;m</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Xu</surname><given-names>Xianpeng</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Liang</surname><given-names>Zhide</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Fangfang Zeng, MD, Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601, Huangpu Avenue West, Tianhe District, Guangzhou, 510632, China, 86 2085221343; <email>zengffjnu@126.com</email></corresp><fn fn-type="equal" id="equal-contrib1"><label>*</label><p>these authors contributed equally</p></fn></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>28</day><month>7</month><year>2025</year></pub-date><volume>12</volume><elocation-id>e66950</elocation-id><history><date date-type="received"><day>27</day><month>09</month><year>2024</year></date><date date-type="rev-recd"><day>21</day><month>03</month><year>2025</year></date><date date-type="accepted"><day>06</day><month>04</month><year>2025</year></date></history><copyright-statement>&#x00A9; Yun Han, Jiamin Qiu, Chengbin Shi, Shiqi Huang, Haokun Huang, Xinman Wang, Sui Zhu, Dalin Lu, Peng Lu, Fangfang Zeng. Originally published in JMIR Mental Health (<ext-link ext-link-type="uri" xlink:href="https://mental.jmir.org">https://mental.jmir.org</ext-link>), 28.7.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Mental Health, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://mental.jmir.org/">https://mental.jmir.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://mental.jmir.org/2025/1/e66950"/><abstract><sec><title>Background</title><p>Digital addiction, affecting a significant portion of the population, particularly young people, is linked to psychological issues and social problems, making its prevention and management a crucial public health issue.</p></sec><sec><title>Objective</title><p>This umbrella review aimed to comprehensively analyze the factors influencing digital addiction by re-evaluating the methodologies and evidence quality of existing meta-analyses.</p></sec><sec sec-type="methods"><title>Methods</title><p>Databases including PubMed, Web of Science, the Cochrane Library, and Embase were systematically searched for reviews and meta-analyses related to factors associated with digital addiction up to September 24, 2024. The methodological quality of the identified studies was assessed using the modified &#x201C;A Measurement Tool to Assess Systematic Reviews 2&#x201D; (AMSTAR 2) tool, while the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool was used to evaluate the quality of the evidence presented in the literature.</p></sec><sec sec-type="results"><title>Results</title><p>A total of 18 articles were included in the review, with AMSTAR 2 assessments revealing 6 moderate-quality, 4 low-quality, and 8 very low-quality studies. In total, 29 significant factors associated with digital addiction were identified. Notably, 4 studies achieved both moderate AMSTAR 2 and GRADE ratings, indicating that positive parent-child relationship (<italic>r</italic>=&#x2212;0.15, 95% CI&#x2212;0.18 to &#x2212;0.11; <italic>P</italic>&#x003C;.05) effectively mitigate the risks of digital addiction. Conversely, urban residence (odds ratio [OR] 2.32, 95% CI 1.19-4.53; <italic>P</italic>&#x003C;.001), adverse childhood experiences (<italic>r</italic>=0.21, 95% CI 0.18-0.24; <italic>P</italic>&#x003C;.001), and social anxiety (<italic>r</italic>=0.34, 95% CI 0.19-0.48; <italic>P</italic>&#x003C;.001) were identified as factors that may increase the risk of developing digital addiction.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>This study found that social factors such as urban residence were associated with an increased risk of digital addiction, whereas social support served as a protective factor against this risk. Nonetheless, the methodologies used in analyzing the factors related to digital addiction require further refinement.</p></sec><sec><title>Trial Registration</title><p>PROSPERO CRD42024594911; <ext-link ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/PROSPERO/view/CRD42024594911">https://www.crd.york.ac.uk/PROSPERO/view/CRD42024594911</ext-link></p></sec></abstract><kwd-group><kwd>digital addiction</kwd><kwd>influencing factor</kwd><kwd>umbrella review</kwd><kwd>meta-analysis</kwd><kwd>youth</kwd><kwd>adolescents</kwd><kwd>teenager</kwd><kwd>urban</kwd><kwd>AMSTAR 2</kwd><kwd>GRADE</kwd><kwd>adverse childhood experiences</kwd><kwd>social anxiety</kwd><kwd>psychological</kwd><kwd>psychology</kwd><kwd>social problem</kwd><kwd>social support</kwd><kwd>methodologies</kwd><kwd>public health</kwd><kwd>digital health</kwd><kwd>mental health</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>Digital addiction is characterized by a detrimental dependence on digital media and high-tech devices, including social networking, smartphone, and internet addictions [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. Although digital addiction is not officially classified as a diagnosable disorder, some psychologists argue that it bears similarities to substance use disorders [<xref ref-type="bibr" rid="ref3">3</xref>]. It is estimated that smartphone addiction affected 26.99% of individuals, social media addiction 17.42%, and internet addiction 14.22%, with notably higher rates among young people [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. A cross-sectional study involving 31,659 university students from 2015 to 2018 revealed prevalence rates of 37.93% (12,009/31,659) for mild, 6.33% (2003/31,659) for moderate, and 0.20% (63/31,659) for severe internet addiction [<xref ref-type="bibr" rid="ref5">5</xref>]. Digital addiction contributes to psychological issues, including attention deficits, depression, and anxiety, while also exacerbating social isolation, sleep disorders, and diminishing academic and occupational performance [<xref ref-type="bibr" rid="ref6">6</xref>]. Consequently, the effective prevention and management of digital addiction has emerged as a critical public health concern [<xref ref-type="bibr" rid="ref7">7</xref>].</p><p>Studies have sought to identify modifiable risk and protective factors associated with digital addiction, categorizing them into three main domains, namely individual, digital media, and environment [<xref ref-type="bibr" rid="ref7">7</xref>-<xref ref-type="bibr" rid="ref11">11</xref>]. The emphasis has primarily been on individual and social determinants, which encompass intrapersonal and interpersonal factors, including gender differences, psychological traits, and health behaviors, as well as broader social influences. Despite the existence of numerous systematic reviews and meta-analyses addressing factors linked to digital addiction, these investigations often focus on specific individual factors without providing updated, comprehensive insights. It is notable that 1 study identified 34 modifiable factors such as intrapersonal factors (eg, time spent playing and psychological conditioning), interpersonal factors, and social factors and concluded that intrapersonal factors were more likely to have a greater impact on internet gaming disorder [<xref ref-type="bibr" rid="ref8">8</xref>]. However, this study&#x2019;s focus on internet gaming disorder represents only 1 facet of the broader spectrum of digital addiction.</p><p>Umbrella review is an emerging evidence synthesis method that evaluates multiple meta-analyses on related topics to derive more comprehensive conclusions. Unlike traditional meta-analyses, umbrella reviews assess the methodological quality and risk of bias across various studies, enhancing the ability to detect inconsistencies and differences in findings [<xref ref-type="bibr" rid="ref12">12</xref>]. This approach offers a broader understanding of the credibility and robustness of the evidence, helping to identify potential heterogeneity and diversity among studies.</p><p>This study aimed to further promote the integration of different research findings by conducting a comprehensive analysis of existing influences on digital addiction through umbrella analyses, while also evaluating the methodology and quality of existing meta-analyses and systematic reviews.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Study Design</title><p>This umbrella review was conducted in accordance with the registered protocol (Open Science Framework Registry) and the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 statement [<xref ref-type="bibr" rid="ref13">13</xref>]. Our study protocol has been registered with PROSPERO (registration number CRD42024594911).</p></sec><sec id="s2-2"><title>Literature Search Strategy</title><p>This study followed the umbrella review process established by Aromataris et al [<xref ref-type="bibr" rid="ref12">12</xref>], searched databases such as PubMed, Web of Science, the Cochrane Library, and Embase, and selected systematic reviews and meta-analyses on the influencing factors of digital addiction included in the databases up to September 24, 2024. The keywords used included digital addiction, digital overuse, internet addiction, internet-based addiction, problematic internet use, gaming disorder, social media addiction, influencing factors, risk factors, causative factors, contributing factors, meta-analysis, and systematic review, etc, and the search was conducted using a combination of subject words and free words. Taking the PubMed database as an example, the search strategy was shown in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>. We also hand-searched the references of eligible included studies and google scholar to identify further relevant articles.</p></sec><sec id="s2-3"><title>Inclusion and Exclusion Criteria</title><p>We included studies on the influencing factors of digital addiction if they met the following inclusion criteria: (1) study type was systematic reviews and meta-analyses; (2) studies that focused on the various determinants of any type of digital addiction across different populations; (3) studies that reported the overall effect size, including but not limited to pooled Pearson correlation coefficients or Spearman rank correlation coefficients (<italic>r</italic>), standardized mean difference, and odds ratio (OR) along with their 95% CIs or credible intervals.</p><p>Meta-analyses focusing exclusively on a single influencing factor were selected, prioritizing the most recent study with the largest number of included studies when duplicates were present [<xref ref-type="bibr" rid="ref14">14</xref>]. When multiple systematic reviews addressed the same influencing factor, only the most recent review with the largest number of individual studies providing study-level estimates was included to prevent sample duplication. No language or date restrictions were applied. Articles lacking study-level effect sizes and 95% CIs for systematic reviews, or those based on animal models, were excluded. In addition, we excluded conference abstracts, editorials, narrative reviews, and systematic review protocols.</p></sec><sec id="s2-4"><title>Literature Screening and Data Extraction</title><p>This study was conducted by 2 researchers who screened the literature and extracted data according to the inclusion and exclusion criteria. In case of disagreement, consulting a third researcher (ZFF) assisted in making the decision. Duplicate literatures were eliminated through the title and abstract, and the full texts were carefully read to extract information such as the first author, publication time, number of studies included and sample size, exposure factors, main outcome indicators, meta-analysis effect model, effect size and its 95% CI. When the same meta-analysis contained multiple health outcome indicators, each outcome indicator was extracted separately.</p></sec><sec id="s2-5"><title>Literature Quality Assessment</title><p>In this study, the modified version of the systematic review methodology quality assessment tool (AMSTAR 2 [A Measurement Tool to Assess Systematic Reviews 2]) was used to assess the methodological quality of systematic studies [<xref ref-type="bibr" rid="ref15">15</xref>]. AMSTAR 2 evaluated the methodological quality and credibility of the study from 16 items in 3 dimensions (including 7 key items and 9 non&#x2013;key items) such as research design and registration, literature search and selection, quality assessment of the study, and data extraction. It demonstrated good inter-rater consistency, practicality, and a wide range of applications. Referencing the interpretation by Zeng et al [<xref ref-type="bibr" rid="ref16">16</xref>], it was considered that &#x2264;1 non&#x2013;key item not met was high-quality research, &#x2265;2 non&#x2013;key items not met was medium-quality research, 1 key item not met was low-quality research, and &#x2265;2 key items not met was extremely low-quality research.</p><p>The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool was used to evaluate the evidence quality level of the literature [<xref ref-type="bibr" rid="ref17">17</xref>]. The GRADE grading system evaluated the outcome indicators based on 5 downgrade factors such as limitations, heterogeneity, indirectness, imprecision, and publication bias. This study stipulated that no downgrade factors were high-quality evidence, the existence of 1 downgrade factor was medium-quality evidence, the existence of 2 downgrade factors was low-quality evidence, and downgrade factors &#x2265;3 were extremely low-quality evidence [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>]. While the GRADE system typically assigns an initial &#x201C;very low&#x201D; quality rating to evidence derived from observational studies due to inherent limitations such as potential confounding and bias, it allows for upgrading or downgrading based on additional factors such as the magnitude of effect, dose-response relationships, and the presence of plausible confounding factors. In this umbrella review, we applied the GRADE framework to evaluate the quality of evidence across meta-analyses, which often include a mix of observational and other study designs. This approach enables a more nuanced assessment of the evidence, considering factors such as risk of bias, inconsistency, indirectness, imprecision, and publication bias. By doing so, we aimed to provide a comprehensive evaluation of the credibility and robustness of the findings related to digital addiction.</p></sec><sec id="s2-6"><title>Data Analysis</title><p>This study conducted a methodological assessment using AMSTAR 2 and evaluated the quality of evidence with GRADE, aiming to identify high-quality and significant results from the most up-to-date and comprehensive available evidence. Significant heterogeneity was defined as present when the <italic>I&#x00B2;</italic>&#x003E;50% or the <italic>P</italic>&#x003C;.1 [<xref ref-type="bibr" rid="ref20">20</xref>]. A meta-analysis was considered to have a small sample size if there were fewer than 1000 participants in the meta-analysis [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>]. Notably, a significant publication bias was inferred if the largest weighted effect size in the meta-analysis was subordinate to the overall effect size, indicating a significant small study effect (SSE) [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. Publication bias was quantitatively assessed using the Egger test [<xref ref-type="bibr" rid="ref24">24</xref>] and the Begg test [<xref ref-type="bibr" rid="ref25">25</xref>], with a <italic>P</italic> value &#x003C;.05 [<xref ref-type="bibr" rid="ref26">26</xref>] indicating the presence of statistically significant bias.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Literature Screening Results and Basic Characteristics</title><p>Through a database search and additional manual search, a total of 912 relevant articles were initially identified. After removing duplicates, 536 articles remained. Following a review of titles and abstracts, 387 articles were excluded (266 due to mismatched study types and 151 for being irrelevant). After full-text screening and reviewing in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>, 101 articles were further excluded due to incomplete data or lack of effect size. As illustrated in <xref ref-type="fig" rid="figure1">Figure 1</xref>, the final selection process resulted in the inclusion of 18 articles that met the inclusion criteria.</p><p>The included meta-analyses were published between 2020 and 2024, reporting on 24 potential influencing factors related to digital addiction, with personality traits further subdivided into 8 categories. The sample sizes of the studies ranged from 300 to 159,425 participants. The included literature mainly used the New Castle-Ottawa scale (NOS) and the Joanna Briggs Institute (JBI) systematic review checklist to assess research quality. A total 6 studies did not specify the methods used for quality evaluation or risk of bias assessment. The basic characteristics of the included literatures are seen in <xref ref-type="table" rid="table1">Table 1</xref>.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>PRISMA flow diagram of the search and selection process.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="mental_v12i1e66950_fig01.png"/></fig><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>The basic characteristics of the studies.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Study</td><td align="left" valign="bottom">Region</td><td align="left" valign="bottom">Study design of included study</td><td align="left" valign="bottom">Studies</td><td align="left" valign="bottom">Cases</td><td align="left" valign="bottom">Influencing factor</td><td align="left" valign="bottom">Outcomes</td><td align="left" valign="bottom">Quality assessment</td><td align="left" valign="bottom">I2 values (%)</td><td align="left" valign="bottom"><italic>P</italic> value of publication bias</td><td align="left" valign="bottom">SSE<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup></td></tr></thead><tbody><tr><td align="left" valign="top">Akbari et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref27">27</ext-link></underline>]</td><td align="left" valign="top">Iran</td><td align="left" valign="top">Case-control, cohort, experimental study, cross-sectional</td><td align="left" valign="top">85</td><td align="left" valign="top">55,134</td><td align="left" valign="top">Fear of missing out</td><td align="left" valign="top">Internet addiction</td><td align="left" valign="top">&#x2014;<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td><td align="left" valign="top">58.37</td><td align="left" valign="top">0.23</td><td align="left" valign="top">No</td></tr><tr><td align="left" valign="top">Chung et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref7">7</ext-link></underline>]</td><td align="left" valign="top">Taiwan (China)</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">5</td><td align="left" valign="top">300</td><td align="left" valign="top">Probability discounting</td><td align="left" valign="top">Internet gaming disorder</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">85.66</td><td align="left" valign="top">&#x003C;.01</td><td align="left" valign="top">Yes</td></tr><tr><td align="left" valign="top">Mak et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref28">28</ext-link></underline>]</td><td align="left" valign="top">Korea</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">37</td><td align="left" valign="top">34,438</td><td align="left" valign="top">Neuroticism</td><td align="left" valign="top">Facebook addiction</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">96</td><td align="left" valign="top">&#x003E;.05</td><td align="left" valign="top">Yes</td></tr><tr><td align="left" valign="top">Noroozi et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref29">29</ext-link></underline>]</td><td align="left" valign="top">Iran</td><td align="left" valign="top">Cross-sectional, case-control, and cohort</td><td align="left" valign="top">18</td><td align="left" valign="top">2589</td><td align="left" valign="top">Quality of life</td><td align="left" valign="top">Internet addiction</td><td align="left" valign="top">STROBE<sup><xref ref-type="table-fn" rid="table1fn3">c</xref></sup></td><td align="left" valign="top">85.23</td><td align="left" valign="top">0.6</td><td align="left" valign="top">Yes</td></tr><tr><td align="left" valign="top">B&#x00E4;cklund et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref30">30</ext-link></underline>]</td><td align="left" valign="top">Sweden</td><td align="left" valign="top">Cross-sectional, longitudinal</td><td align="left" valign="top">46</td><td align="left" valign="top">49,192</td><td align="left" valign="top">Gaming motivations</td><td align="left" valign="top">Gaming disorder</td><td align="left" valign="top">JBI checklist<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">96</td><td align="left" valign="top">ND</td><td align="left" valign="top">No</td></tr><tr><td align="left" valign="top">Ding et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref31">31</ext-link></underline>]</td><td align="left" valign="top">China</td><td align="left" valign="top">Cross-sectional</td><td align="left" valign="top">14</td><td align="left" valign="top">11,561</td><td align="left" valign="top">Self-esteem</td><td align="left" valign="top">Smartphone addiction</td><td align="left" valign="top">JBI checklist</td><td align="left" valign="top">74</td><td align="left" valign="top">0.9</td><td align="left" valign="top">No</td></tr><tr><td align="left" valign="top">Eirich et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref32">32</ext-link></underline>]</td><td align="left" valign="top">Canada</td><td align="left" valign="top">Observational, experimental</td><td align="left" valign="top">87</td><td align="left" valign="top">159,425</td><td align="left" valign="top">Behavior problems</td><td align="left" valign="top">Screen time overuse</td><td align="left" valign="top">JBI checklist</td><td align="left" valign="top">87.8</td><td align="left" valign="top">ND</td><td align="left" valign="top">No</td></tr><tr><td align="left" valign="top">Hao et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref33">33</ext-link></underline>]</td><td align="left" valign="top">China</td><td align="left" valign="top">Case-control, cross-sectional</td><td align="left" valign="top">26</td><td align="left" valign="top">14,638</td><td align="left" valign="top">Personal relationship</td><td align="left" valign="top">Internet addiction</td><td align="left" valign="top">NOS<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td><td align="left" valign="top">94.1</td><td align="left" valign="top">&#x003E;.05</td><td align="left" valign="top">Yes</td></tr><tr><td align="left" valign="top">Li et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref34">34</ext-link></underline>]</td><td align="left" valign="top">China</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">50</td><td align="left" valign="top">38,488</td><td align="left" valign="top">Academic burnout</td><td align="left" valign="top">Problematic mobile phone use</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">91.71</td><td align="left" valign="top">0.83</td><td align="left" valign="top">No</td></tr><tr><td align="left" valign="top">Rajesh et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref35">35</ext-link></underline>]</td><td align="left" valign="top">India</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">96</td><td align="left" valign="top">35,608</td><td align="left" valign="top">Personality traits</td><td align="left" valign="top">Facebook addiction</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">84.27</td><td align="left" valign="top">&#x003E;.05</td><td align="left" valign="top">No</td></tr><tr><td align="left" valign="top">Wang et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref36">36</ext-link></underline>]</td><td align="left" valign="top">China</td><td align="left" valign="top">Observational</td><td align="left" valign="top">31</td><td align="left" valign="top">29,692</td><td align="left" valign="top">Negative life events</td><td align="left" valign="top">Internet addiction</td><td align="left" valign="top">NOS</td><td align="left" valign="top">97.8</td><td align="left" valign="top">0.36</td><td align="left" valign="top">No</td></tr><tr><td align="left" valign="top">Zewde et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref37">37</ext-link></underline>]</td><td align="left" valign="top">Ethiopia</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">145</td><td align="left" valign="top">15,316<break/>7234</td><td align="left" valign="top">Male<break/>Urban residence</td><td align="left" valign="top">Internet addiction<break/>Internet addiction</td><td align="left" valign="top">&#x2014;<break/>&#x2014;</td><td align="left" valign="top">&#x003C;0.01<break/>51.81</td><td align="left" valign="top">.82<break/>.94</td><td align="left" valign="top">Yes<break/>No</td></tr><tr><td align="left" valign="top">Hidalgo-Fuentes et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref38">38</ext-link></underline>]</td><td align="left" valign="top">Spain</td><td align="left" valign="top">Original empirical, quantitative cross-sectional, longitudinal</td><td align="left" valign="top">19</td><td align="left" valign="top">93,859</td><td align="left" valign="top">Resilience</td><td align="left" valign="top">Problematic internet use</td><td align="left" valign="top">NOS</td><td align="left" valign="top">97.46</td><td align="left" valign="top">0.76</td><td align="left" valign="top">No</td></tr><tr><td align="left" valign="top">Niu et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref39">39</ext-link></underline>]</td><td align="left" valign="top">China</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">3424</td><td align="left" valign="top">32,587<break/>21,366</td><td align="left" valign="top">Positive parenting styles<break/>Negative parenting styles</td><td align="left" valign="top">Problematic internet use<break/>Problematic internet use</td><td align="left" valign="top">NOS<break/>NOS</td><td align="left" valign="top">41.77<break/>30.43</td><td align="left" valign="top">.45<break/>.39</td><td align="left" valign="top">No<break/>No</td></tr><tr><td align="left" valign="top">Wan et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref40">40</ext-link></underline>]</td><td align="left" valign="top">China</td><td align="left" valign="top">Observational</td><td align="left" valign="top">9229</td><td align="left" valign="top">59,716<break/>21,844</td><td align="left" valign="top">Social support<break/>Self-control</td><td align="left" valign="top">Mobile phone addiction<break/>Smartphone addiction</td><td align="left" valign="top">JBI checklist<break/>JBI checklist</td><td align="left" valign="top">96.10<break/>96.30</td><td align="left" valign="top">.81<break/>.19</td><td align="left" valign="top">No<break/>No</td></tr><tr><td align="left" valign="top">Zhuang et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref8">8</ext-link></underline>]</td><td align="left" valign="top">China</td><td align="left" valign="top">Longitudinal, prospective, cohort</td><td align="left" valign="top">12<break/>7<break/>10<break/>5</td><td align="left" valign="top">9113<break/>8444<break/>9364<break/>5819</td><td align="left" valign="top">Depression<break/>Gaming time<break/>Parent-child relationship<break/>Grade point average</td><td align="left" valign="top">Internet gaming disorder<break/>Internet gaming disorder<break/>Internet gaming disorder<break/>Internet gaming disorder</td><td align="left" valign="top">NOS<break/>NOS<break/>NOS<break/>NOS</td><td align="left" valign="top">89.32<break/>97.07<break/>62.54<break/>92.46</td><td align="left" valign="top">.58<break/>.80<break/>.34<break/>.47</td><td align="left" valign="top">No<break/>No<break/>No<break/>No</td></tr><tr><td align="left" valign="top">Hao et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref41">41</ext-link></underline>]</td><td align="left" valign="top">China</td><td align="left" valign="top">Longitudinal, cross-sectional</td><td align="left" valign="top">37</td><td align="left" valign="top">45,364</td><td align="left" valign="top">Childhood adverse experiences</td><td align="left" valign="top">Internet addiction</td><td align="left" valign="top">NOS</td><td align="left" valign="top">91</td><td align="left" valign="top">&#x003E;.05</td><td align="left" valign="top">No</td></tr><tr><td align="left" valign="top">Wu et al [<underline><ext-link ext-link-type="uri" xlink:href="https://kriya2.kriyadocs.com/web_preview?doi=66950&#x0026;project=mental&#x0026;customer=jmir#ref42">42</ext-link></underline>]</td><td align="left" valign="top">China</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">53</td><td align="left" valign="top">59,928</td><td align="left" valign="top">Social anxiety</td><td align="left" valign="top">Problematic social media use</td><td align="left" valign="top">The Agency for Healthcare Research and Quality&#x2019;s Research Literature Quality Assessment Inventory</td><td align="left" valign="top">92.91</td><td align="left" valign="top">&#x003C;.01</td><td align="left" valign="top">No</td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>SSE: small study effect.</p></fn><fn id="table1fn2"><p><sup>b</sup>Not mentioned.</p></fn><fn id="table1fn3"><p><sup>c</sup>STROBE: Strengthening the Reporting of Observational Studies in Epidemiology.</p></fn><fn id="table1fn4"><p><sup>d</sup>JBI checklist: Joanna Briggs Institution Critical Appraisal Checklist.</p></fn><fn id="table1fn5"><p><sup>e</sup>NOS: Newcastle-Ottawa scale.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-3"><title>Methodological Quality Evaluation</title><p>Through evaluation with the AMSTAR-2 tool, all included meta-analyses exhibited some methodological deficiencies. Specifically, 6 were of moderate quality, 4 of low quality, and 8 of very low quality, with none classified as high quality. For key items, the compliance rates were as follows: item #2 (whether the review reported that its methods were established a priori and explained any major changes to the protocol), item #4 (whether a comprehensive literature search was conducted), item #7 (whether a list of excluded studies and reasons for exclusion were provided), and item #9 (whether a satisfactory technique for assessing the risk of bias in individual studies was used) all had a compliance rate of 83.33% (15/18); the compliance rate for item #11 (whether appropriate methods were used to combine results) was 72.22% (13/18); item #13 (whether bias was explained) had a compliance rate of 33.33% (6/18); and item #15 (whether the authors properly investigated and discussed the potential impact of publication bias) was 55.56% (10/18). The results of the methodological quality evaluation are presented in <xref ref-type="table" rid="table2">Table 2</xref>.</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Methodological quality evaluation.</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" rowspan="2">Study</td><td align="left" valign="bottom" colspan="16">Items</td><td align="left" valign="bottom" rowspan="2">Methodological quality</td></tr><tr><td align="left" valign="bottom">#1<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td><td align="left" valign="bottom">#2<sup><xref ref-type="table-fn" rid="table2fn2">b</xref></sup></td><td align="left" valign="bottom">#3<sup><xref ref-type="table-fn" rid="table2fn3">c</xref></sup></td><td align="left" valign="bottom">#4<sup><xref ref-type="table-fn" rid="table2fn4">d</xref></sup></td><td align="left" valign="bottom">#5<sup><xref ref-type="table-fn" rid="table2fn5">e</xref></sup></td><td align="left" valign="bottom">#6<sup><xref ref-type="table-fn" rid="table2fn6">f</xref></sup></td><td align="left" valign="bottom">#7<sup><xref ref-type="table-fn" rid="table2fn7">g</xref></sup></td><td align="left" valign="bottom">#8<sup><xref ref-type="table-fn" rid="table2fn8">h</xref></sup></td><td align="left" valign="bottom">#9<sup><xref ref-type="table-fn" rid="table2fn9">i</xref></sup></td><td align="left" valign="bottom">#10<sup><xref ref-type="table-fn" rid="table2fn10">j</xref></sup></td><td align="left" valign="bottom">#11<sup><xref ref-type="table-fn" rid="table2fn11">k</xref></sup></td><td align="left" valign="bottom">#12<sup><xref ref-type="table-fn" rid="table2fn12">l</xref></sup></td><td align="left" valign="bottom">#13<sup><xref ref-type="table-fn" rid="table2fn13">m</xref></sup></td><td align="left" valign="bottom">#14<sup><xref ref-type="table-fn" rid="table2fn14">n</xref></sup></td><td align="left" valign="bottom">#15<sup><xref ref-type="table-fn" rid="table2fn15">o</xref></sup></td><td align="left" valign="bottom">#16<sup><xref ref-type="table-fn" rid="table2fn16">p</xref></sup></td></tr></thead><tbody><tr><td align="left" valign="top">Akbari et al [<xref ref-type="bibr" rid="ref27">27</xref>]</td><td align="left" valign="top">Y<sup><xref ref-type="table-fn" rid="table2fn17">q</xref></sup></td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N<sup><xref ref-type="table-fn" rid="table2fn18">r</xref></sup></td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Chung et al [<xref ref-type="bibr" rid="ref28">28</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Mak et al [<xref ref-type="bibr" rid="ref29">29</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Noroozi et al [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">B&#x00E4;cklund et al [<xref ref-type="bibr" rid="ref31">31</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">PY<sup><xref ref-type="table-fn" rid="table2fn19">s</xref></sup></td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">PY</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Ding et al [<xref ref-type="bibr" rid="ref32">32</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Moderate</td></tr><tr><td align="left" valign="top">Eirich et al [<xref ref-type="bibr" rid="ref33">33</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Hao et al [<xref ref-type="bibr" rid="ref34">34</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Li et al [<xref ref-type="bibr" rid="ref35">35</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Rajesh et al [<xref ref-type="bibr" rid="ref36">36</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Wan et al [<xref ref-type="bibr" rid="ref37">37</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Moderate</td></tr><tr><td align="left" valign="top">Wang et al [<xref ref-type="bibr" rid="ref38">38</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">PY</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Zewde et al [<xref ref-type="bibr" rid="ref39">39</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Moderate</td></tr><tr><td align="left" valign="top">Hidalgo-Fuentes et al [<xref ref-type="bibr" rid="ref40">40</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Niu et al [<xref ref-type="bibr" rid="ref41">41</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">PY</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Zhuang et al [<xref ref-type="bibr" rid="ref8">8</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Moderate</td></tr><tr><td align="left" valign="top">Hao et al [<xref ref-type="bibr" rid="ref42">42</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Moderate</td></tr><tr><td align="left" valign="top">Wu et al [<xref ref-type="bibr" rid="ref43">43</xref>]</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">PY</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Moderate</td></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>#1-Did the research questions and inclusion criteria for the review include the components of PICO?</p></fn><fn id="table2fn2"><p><sup>b</sup>#2-Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol?</p></fn><fn id="table2fn3"><p><sup>c</sup>#3-Did the review authors explain their selection of the study designs for inclusion in the review?</p></fn><fn id="table2fn4"><p><sup>d</sup>#4-Did the review authors use a comprehensive literature search strategy?</p></fn><fn id="table2fn5"><p><sup>e</sup>#5-Did the review authors perform study selection in duplicate?</p></fn><fn id="table2fn6"><p><sup>f</sup>#6-Did the review authors perform data extraction in duplicate?</p></fn><fn id="table2fn7"><p><sup>g</sup>#7-Did the review authors provide a list of excluded studies and justify the exclusions?</p></fn><fn id="table2fn8"><p><sup>h</sup>#8-Did the review authors describe the included studies in adequate detail?</p></fn><fn id="table2fn9"><p><sup>i</sup>#9-Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review?</p></fn><fn id="table2fn10"><p><sup>j</sup>#10-Did the review authors report on the sources of funding for the studies included in the review?</p></fn><fn id="table2fn11"><p><sup>k</sup>#11-If meta-analysis was performed did the review authors use appropriate methods for statistical combination of results?</p></fn><fn id="table2fn12"><p><sup>l</sup>#12-If meta-analysis was performed, did the review authors assess the potential impact of RoB in individual studies on the results of the meta-analysis or other evidence synthesis?</p></fn><fn id="table2fn13"><p><sup>m</sup>#13-Did the review authors account for RoB in individual studies when interpreting/discussing the results of the review?</p></fn><fn id="table2fn14"><p><sup>n</sup>#14-Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review?</p></fn><fn id="table2fn15"><p><sup>o</sup>#15-If they performed quantitative synthesis did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review?</p></fn><fn id="table2fn16"><p><sup>p</sup>#16-Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review?</p></fn><fn id="table2fn17"><p><sup>q</sup>Y: complaint.</p></fn><fn id="table2fn18"><p><sup>r</sup>N: not complaint.</p></fn><fn id="table2fn19"><p><sup>s</sup>PY: partially complaint.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-4"><title>Evidence Quality Grading</title><p>Based on the GRADE evaluation system, of the 24 outcome indicators, 1 study provided high-quality evidence, 5 provided moderate-quality evidence, 11 were of low quality, and 7 were of very low quality. The detailed results of the evidence quality assessment are presented in <xref ref-type="table" rid="table3">Table 3</xref>.</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>Evidence quality grading.</p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom"/><td align="left" valign="bottom"/><td align="left" valign="bottom" colspan="6">Downgrading factors</td></tr><tr><td align="left" valign="bottom">Study</td><td align="left" valign="bottom">Influencing Factor</td><td align="left" valign="bottom">Risk of Bias<sup><xref ref-type="table-fn" rid="table3fn1">a</xref></sup></td><td align="left" valign="bottom">Inconsistency<sup><xref ref-type="table-fn" rid="table3fn2">b</xref></sup></td><td align="left" valign="bottom">Indirectness<sup><xref ref-type="table-fn" rid="table3fn3">c</xref></sup></td><td align="left" valign="bottom">Imprecision<sup><xref ref-type="table-fn" rid="table3fn4">d</xref></sup></td><td align="left" valign="bottom">Publication Bias<sup><xref ref-type="table-fn" rid="table3fn5">e</xref></sup></td><td align="left" valign="bottom">Evidence Quality</td></tr></thead><tbody><tr><td align="left" valign="top">Akbari et al [<xref ref-type="bibr" rid="ref27">27</xref>]</td><td align="left" valign="top">Fear of missing out</td><td align="left" valign="top">Y<sup><xref ref-type="table-fn" rid="table3fn6">f</xref></sup></td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N<sup><xref ref-type="table-fn" rid="table3fn7">g</xref></sup></td><td align="left" valign="top">N</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Chung et al [<xref ref-type="bibr" rid="ref28">28</xref>]</td><td align="left" valign="top">Probability discounting</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">High</td></tr><tr><td align="left" valign="top">Mak et al [<xref ref-type="bibr" rid="ref29">29</xref>]</td><td align="left" valign="top">Personality traits</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Noroozi et al [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">Quality of life</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">B&#x00E4;cklund et al [<xref ref-type="bibr" rid="ref31">31</xref>]</td><td align="left" valign="top">Gaming motivations</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top" rowspan="2">Ding et al [<xref ref-type="bibr" rid="ref32">32</xref>]</td><td align="left" valign="top">Self-esteem</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Self-control</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Eirich et al [<xref ref-type="bibr" rid="ref33">33</xref>]</td><td align="left" valign="top">Behavior problems</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Hao et al [<xref ref-type="bibr" rid="ref34">34</xref>]</td><td align="left" valign="top">Personal relationship</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Li et al [<xref ref-type="bibr" rid="ref35">35</xref>]</td><td align="left" valign="top">Academic burnout</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Rajesh et al [<xref ref-type="bibr" rid="ref36">36</xref>]</td><td align="left" valign="top">Personality traits</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Moderate</td></tr><tr><td align="left" valign="top">Wan et al [<xref ref-type="bibr" rid="ref37">37</xref>]</td><td align="left" valign="top">Social support</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Wang et al [<xref ref-type="bibr" rid="ref38">38</xref>]</td><td align="left" valign="top">Negative life events</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top" rowspan="2">Zewde et al [<xref ref-type="bibr" rid="ref39">39</xref>]</td><td align="left" valign="top">Gender</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Urban residence</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Moderate</td></tr><tr><td align="left" valign="top">Hidalgo-Fuentes et al [<xref ref-type="bibr" rid="ref40">40</xref>]</td><td align="left" valign="top">Resilience</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top" rowspan="2">Niu et al [<xref ref-type="bibr" rid="ref41">41</xref>]</td><td align="left" valign="top">Positive parenting styles</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Negative parenting styles</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top" rowspan="4">Zhuang et al [<xref ref-type="bibr" rid="ref8">8</xref>]</td><td align="left" valign="top">Depression</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Gaming time</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">Very low</td></tr><tr><td align="left" valign="top">Parent-child relationship</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Moderate</td></tr><tr><td align="left" valign="top">Grade point average</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Low</td></tr><tr><td align="left" valign="top">Hao et al [<xref ref-type="bibr" rid="ref42">42</xref>]</td><td align="left" valign="top">Childhood adverse experiences</td><td align="left" valign="top">Y</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Moderate</td></tr><tr><td align="left" valign="top">Wu et al [<xref ref-type="bibr" rid="ref43">43</xref>]</td><td align="left" valign="top">Social anxiety</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">N</td><td align="left" valign="top">Y</td><td align="left" valign="top">Moderate</td></tr></tbody></table><table-wrap-foot><fn id="table3fn1"><p><sup>a</sup>Risk of bias: bias occurs when the results of a study do not represent the truth because of inherent limitations in design or conduct of a study</p></fn><fn id="table3fn2"><p><sup>b</sup>Inconsistency: this refers to unexplained variability among the results of the included studies.</p></fn><fn id="table3fn3"><p><sup>c</sup>Indirectness: it refers to the extent to which the people, interventions, and outcome measures are similar to those of interest.</p></fn><fn id="table3fn4"><p><sup>d</sup>Imprecision: the authors have the option of decreasing their level of certainty one or two levels if the confidence intervals are wide.</p></fn><fn id="table3fn5"><p><sup>e</sup>Publication Bias: this occurs when the dissemination of research findings is influenced by the nature and direction of results.</p></fn><fn id="table3fn6"><p><sup>f</sup>Y: compliant.</p></fn><fn id="table3fn7"><p><sup>g</sup>NY: not compliant.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-5"><title>Influencing Factors for Digital Addiction</title><sec id="s3-5-1"><title>Intrapersonal Factors</title><p>As shown in <xref ref-type="table" rid="table4">Table 4</xref> and <xref ref-type="fig" rid="figure2">Figure 2</xref>, most of the included studies were highly significant. In this study, Ding et al [<xref ref-type="bibr" rid="ref32">32</xref>] discovered that individuals with higher levels of self-esteem (<italic>r</italic>=&#x2212;0.25, 95% CI&#x2212;0.29 to &#x2212;0.22; <italic>P</italic>&#x003C;.001) and self-control (<italic>r</italic>=&#x2212;0.48, 95% CI&#x2212;0.53 to &#x2212;0.42; <italic>P</italic>&#x003C;.001) are more prone to digital addiction. Similarly, Zewde et al [<xref ref-type="bibr" rid="ref39">39</xref>] found that men are at a higher risk of digital addiction compared with women (OR 1.92, 95% CI 1.43-2.75; <italic>P</italic>&#x003C;.001). Furthermore, Zhuang et al [<xref ref-type="bibr" rid="ref8">8</xref>] reported that individuals with a higher grade point average (<italic>r</italic>=&#x2212;0.15, 95% CI &#x2212;0.25 to &#x2212;0.16; <italic>P</italic>&#x003C;.05) are less likely to be threatened by digital addiction. These findings were rated as moderate evidence in terms of methodological quality with AMSTAR 2 tool.</p><table-wrap id="t4" position="float"><label>Table 4.</label><caption><p>Factors associated with digital addiction.</p></caption><table id="table4" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Author (Year)</td><td align="left" valign="bottom">Influencing factor</td><td align="left" valign="bottom">Model</td><td align="left" valign="bottom">Confounding adjusted</td><td align="left" valign="bottom">ES<sup><xref ref-type="table-fn" rid="table4fn1">a</xref></sup> (95% CI)</td><td align="left" valign="bottom"><italic>P</italic> value</td></tr></thead><tbody><tr><td align="left" valign="top">Intrapersonal factors</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2003;</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Akbari et al [<xref ref-type="bibr" rid="ref27">27</xref>]</td><td align="left" valign="top">Fear of missing out</td><td align="left" valign="top">Random</td><td align="left" valign="top">No</td><td align="left" valign="top"><italic>r</italic>=0.41 (0.38-0.44)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Li et al [<xref ref-type="bibr" rid="ref35">35</xref>]</td><td align="left" valign="top">Academic burnout</td><td align="left" valign="top">Random</td><td align="left" valign="top">Yes</td><td align="left" valign="top"><italic>r</italic>=0.41 (0.38-0.44)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Chung et al [<xref ref-type="bibr" rid="ref28">28</xref>]</td><td align="left" valign="top">Probability discounting</td><td align="left" valign="top">Random</td><td align="left" valign="top">Yes</td><td align="left" valign="top">Hedges <italic>g</italic>=&#x2212;0.32 (&#x2013;0.85 to &#x2212;0.20)</td><td align="left" valign="top">.470</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Mak et al [<xref ref-type="bibr" rid="ref29">29</xref>]</td><td align="left" valign="top">Neuroticism</td><td align="left" valign="top">Random</td><td align="left" valign="top">No</td><td align="left" valign="top">SMD=0.54 (0.38-0.69)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>B&#x00E4;cklund et al [<xref ref-type="bibr" rid="ref31">31</xref>]</td><td align="left" valign="top">Gaming motivations</td><td align="left" valign="top">Random</td><td align="left" valign="top">No</td><td align="left" valign="top"><italic>r</italic>=0.50 (0.45-0.54)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Ding et al [<xref ref-type="bibr" rid="ref32">32</xref>]</td><td align="left" valign="top">Self-esteem<break/>Self-control</td><td align="left" valign="top">Random<break/>Random</td><td align="left" valign="top">Yes<break/>Yes</td><td align="left" valign="top"><italic>r</italic>=&#x2212;0.25 (&#x2212;0.29 to &#x2212;0.22)<break/><italic>r</italic>=&#x2212;0.48 (&#x2212;0.53 to &#x2212;0.42)</td><td align="left" valign="top">&#x003C;.001<break/>&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Rajesh et al [<xref ref-type="bibr" rid="ref36">36</xref>]</td><td align="left" valign="top">Openness<break/>Agreeableness<break/>Conscientiousness<break/>Loneliness<break/>Narcissism<break/>Impulsivity<break/>Shyness<break/>Extraversion</td><td align="left" valign="top">Random<break/>Random<break/>Random<break/>Random<break/>Random<break/>Random<break/>Random<break/>Random</td><td align="left" valign="top">Yes<break/>Yes<break/>Yes<break/>Yes<break/>Yes<break/>Yes<break/>Yes<break/>Yes</td><td align="left" valign="top"><italic>r</italic>=&#x2212;0.05 (&#x2212;0.08 to &#x2212;0.01)<break/><italic>r</italic>=&#x2212;0.07 (&#x2212;0.10 to &#x2212;0.04)<break/><italic>r</italic>=&#x2212;0.15 (&#x2212;0.18 to &#x2212;0.11)<break/><italic>r</italic>=0.23 (0.18-0.27)<break/><italic>r</italic>=0.23 (0.12-0.33)<break/><italic>r</italic>=0.25 (0.18-0.32)<break/><italic>r</italic>=0.20 (0.14-0.25)<break/><italic>r</italic>=0.01 (0.02-0.04)</td><td align="left" valign="top">&#x003C;.05<break/>&#x003C;.05<break/>&#x003C;.001<break/>&#x003C;.001<break/>NS<sup><xref ref-type="table-fn" rid="table4fn2">b</xref></sup><break/>&#x003C;.001<break/>&#x003C;.001<break/>NS</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Eirich et al [<xref ref-type="bibr" rid="ref33">33</xref>]</td><td align="left" valign="top">Behavior problems</td><td align="left" valign="top">Random</td><td align="left" valign="top">Yes</td><td align="left" valign="top"><italic>r</italic>=0.11 (0.09-0.12)</td><td align="left" valign="top">&#x003C;.05</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Zewde et al [<xref ref-type="bibr" rid="ref39">39</xref>]</td><td align="left" valign="top">Male sex</td><td align="left" valign="top">Fix</td><td align="left" valign="top">No</td><td align="left" valign="top">OR<sup><xref ref-type="table-fn" rid="table4fn3">c</xref></sup> 1.92 (1.43-2.75)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Hidalgo-Fuentes et al [<xref ref-type="bibr" rid="ref40">40</xref>]</td><td align="left" valign="top">Resilience</td><td align="left" valign="top">Random</td><td align="left" valign="top">No</td><td align="left" valign="top"><italic>r</italic>=&#x2212;0.27 (&#x2212;0.32 to &#x2212;0.22)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Zhuang et al [<xref ref-type="bibr" rid="ref8">8</xref>]</td><td align="left" valign="top">Depression<break/>Grade point average<break/>Gaming time</td><td align="left" valign="top">Random<break/>Random<break/>Random</td><td align="left" valign="top">No<break/>No<break/>No</td><td align="left" valign="top"><italic>r</italic>=0.18 (0.13-0.23)<break/><italic>r</italic>=&#x2212;0.15 (&#x2212;0.25 to &#x2212;0.16)<break/><italic>r</italic>=0.33 (0.21-0.44)</td><td align="left" valign="top">&#x003C;.05<break/>&#x003C;.05<break/>&#x003C;.05</td></tr><tr><td align="left" valign="top">Interpersonal factors</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2003;</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Hao et al [<xref ref-type="bibr" rid="ref34">34</xref>]</td><td align="left" valign="top">Personal relationship troubles</td><td align="left" valign="top">Random</td><td align="left" valign="top">No</td><td align="left" valign="top"><italic>r</italic>=0.36 (0.35-0.38)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Niu et al [<xref ref-type="bibr" rid="ref41">41</xref>]</td><td align="left" valign="top">Positive parenting styles</td><td align="left" valign="top">Fix</td><td align="left" valign="top">Yes</td><td align="left" valign="top"><italic>r</italic>=&#x2212;0.14 (&#x2212;0.17 to &#x2212;0.11)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Niu et al [<xref ref-type="bibr" rid="ref41">41</xref>]</td><td align="left" valign="top">Negative parenting styles</td><td align="left" valign="top">Fix</td><td align="left" valign="top">Yes</td><td align="left" valign="top"><italic>r</italic>=0.18 (0.14-0.22)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Zhuang et al [<xref ref-type="bibr" rid="ref8">8</xref>]</td><td align="left" valign="top">Parent-child relationship</td><td align="left" valign="top">Random</td><td align="left" valign="top">No</td><td align="left" valign="top"><italic>r</italic>=&#x2212;0.15 (&#x2212;0.18 to &#x2212;0.11)</td><td align="left" valign="top">&#x003C;.05</td></tr><tr><td align="left" valign="top">Social factors</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2003;</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Noroozi et al [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">Quality of life</td><td align="left" valign="top">Random</td><td align="left" valign="top">No</td><td align="left" valign="top">OR 0.39 (0.27-0.55)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Wang et al [<xref ref-type="bibr" rid="ref38">38</xref>]</td><td align="left" valign="top">Negative life events</td><td align="left" valign="top">Random</td><td align="left" valign="top">Yes</td><td align="left" valign="top"><italic>r</italic>=0.31 (0.28-0.34)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Wan et al [<xref ref-type="bibr" rid="ref37">37</xref>]</td><td align="left" valign="top">Social support</td><td align="left" valign="top">Random</td><td align="left" valign="top">Yes</td><td align="left" valign="top"><italic>r</italic>=&#x2212;0.17 (&#x2212;0.21 to &#x2212;0.13)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Zewde et al [<xref ref-type="bibr" rid="ref39">39</xref>]</td><td align="left" valign="top">Urban residence</td><td align="left" valign="top">Random</td><td align="left" valign="top">No</td><td align="left" valign="top">OR 2.32 (1.19-4.53)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Hao et al [<xref ref-type="bibr" rid="ref42">42</xref>]</td><td align="left" valign="top">Childhood adverse experiences</td><td align="left" valign="top">Random</td><td align="left" valign="top">Yes</td><td align="left" valign="top"><italic>r</italic>=0.21 (0.18-0.24)</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Wu et al [<xref ref-type="bibr" rid="ref43">43</xref>]</td><td align="left" valign="top">Social anxiety</td><td align="left" valign="top">Random</td><td align="left" valign="top">Yes</td><td align="left" valign="top"><italic>r</italic>=0.34 (0.19-0.48)</td><td align="left" valign="top">&#x003C;.001</td></tr></tbody></table><table-wrap-foot><fn id="table4fn1"><p><sup>a</sup>ES: effect size.</p></fn><fn id="table4fn2"><p><sup>b</sup>NS: not significant.</p></fn><fn id="table4fn3"><p><sup>c</sup>OR: odds ratio.</p></fn></table-wrap-foot></table-wrap><fig position="float" id="figure2"><label>Figure 2.</label><caption><p>Forest plot of factors associated with digital addiction. AMSTAR 2: a measurement tool to assess systematic reviews version 2; ES: effect size; g: Hedge&#x2019;s g; GRADE: Grading of Recommendations Assessment, Development, and Evaluation; NS: not significant; OR: odds ratio; *: classified as moderate with AMSTAR 2 or GRADE; **: classified as high with AMSTAR 2 or GRADE.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="mental_v12i1e66950_fig02.png"/></fig><p>On the other hand, the quality assessment conducted using the GRADE tool revealed that Chung&#x2019;s analyses, which identified a protective impact of the discount probability against digital addiction (<italic>r</italic>=&#x2212;0.32, 95% CI &#x2212;0.85 to &#x2212;0.20; <italic>P</italic>&#x003C;.47), was graded as high-quality evidence [<xref ref-type="bibr" rid="ref28">28</xref>]. However, the statistical results were not significant. In addition, Rajesh et al [<xref ref-type="bibr" rid="ref36">36</xref>] found that different personality traits have varying impacts on digital addiction was also rated as moderate evidence quality. Specifically, they suggested that individuals with openness (<italic>r</italic>=&#x2212;0.05, 95% CI &#x2212;0.08 to &#x2212;0.01; <italic>P</italic>&#x003C;.05), agreeableness (<italic>r</italic>=&#x2212;0.07, 95% CI &#x2212;0.10 to &#x2212;0.04; <italic>P</italic>&#x003C;.05), and conscientiousness (<italic>r</italic>=&#x2212;0.15, 95% CI &#x2212;0.18 to &#x2212;0.11; <italic>P</italic>&#x003C;.001) were protected against the addictive potential of digital media. Conversely, those experiencing loneliness (<italic>r</italic>=0.23, 95% CI 0.19-0.27; <italic>P</italic>&#x003C;.001), depression (<italic>r</italic>=0.18, 95% CI 0.13-0.23; <italic>P</italic>&#x003C;.05), impulsivity (<italic>r</italic>=0.25, 95% CI 0.18-0.32; <italic>P</italic>&#x003C;.001), and shyness (<italic>r</italic>=0.20, 95% CI 0.14-0.25; <italic>P</italic>&#x003C;.001) are at a greater risk of developing digital addiction. Although no publication bias was found in the above analyses, it is important to emphasize that none of the analyses addressing intrapersonal factors achieved moderate or high ratings in terms of methodology and quality of evidence.</p></sec><sec id="s3-5-2"><title>Interpersonal Factors</title><p>Of the 5 analyses examining interpersonal factors associated with digital addiction, only 1 study by Zhuang et al [<xref ref-type="bibr" rid="ref8">8</xref>] met the criteria for moderate methodological and evidence quality with AMSTAR 2 tool. This study focused on parent-child relationship and showed that the stronger the parent-child relationship (<italic>r</italic>=&#x2212;0.15, 95% CI &#x2212;0.18 to &#x2212;0.11, <italic>P</italic>&#x003C;.05), the lower the probability of digital addiction. No risk of publication bias was identified in this analysis (<xref ref-type="table" rid="table4">Table 4</xref> and <xref ref-type="fig" rid="figure2">Figure 2</xref>).</p></sec><sec id="s3-5-3"><title>Social Factors</title><p>The findings revealed that urban residence (OR 2.32, 95% CI 1.19&#x2010;4.53; <italic>P</italic>&#x003C;.001) by Zewde et al [<xref ref-type="bibr" rid="ref39">39</xref>], exposure to adverse childhood experiences (<italic>r</italic>=0.21, 95% CI 0.18&#x2010;0.24; <italic>P</italic>&#x003C;.001) by Hao et al [<xref ref-type="bibr" rid="ref42">42</xref>], and the presence of social anxiety (<italic>r</italic>=0.34, 95% CI 0.19&#x2010;0.48; <italic>P</italic>&#x003C;.001) by Wu et al [<xref ref-type="bibr" rid="ref43">43</xref>] were significant predictors of digital addiction. Notably, all 3 analyses were accorded moderate ratings in the evaluation of methodological and the quality of evidence rating with AMSTAR 2 and GRADE tools, and no evidence of publication bias was identified in the analyses. Furthermore, Wan et al [<xref ref-type="bibr" rid="ref37">37</xref>] suggesting that individuals with stronger social support networks (<italic>r</italic>=&#x2212;0.17, 95% CI &#x2212;0.21 to &#x2212;0.13, <italic>P</italic>&#x003C;.001) exhibited a reduced likelihood of developing digital addiction. However, this particular analysis did not achieve a similar assessment in the quality of evidence, although it was recognized for its moderate methodological quality (<xref ref-type="table" rid="table4">Table 4</xref> and <xref ref-type="fig" rid="figure2">Figure 2</xref>).</p></sec></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>This umbrella review identified a range of intra-personal, interpersonal, and social factors influencing digital addiction. In a comprehensive examination of the aforementioned factors, several studies were noted for their methodological assessment. The studies conducted by Ding et al [<xref ref-type="bibr" rid="ref32">32</xref>] on self-esteem and self-control, by Zewde et al [<xref ref-type="bibr" rid="ref39">39</xref>] on male gender, and by Wan et al [<xref ref-type="bibr" rid="ref37">37</xref>] on social support, all achieved moderate rankings for methodological rigor. However, the evidence for these factors was considered circumstantial or questionable in accuracy, resulting in a classification of low quality. On the other hand, study by Zhuang et al [<xref ref-type="bibr" rid="ref8">8</xref>] concluded that a strong parent-child relationship significantly mitigated digital addiction, while study by Zewde et al [<xref ref-type="bibr" rid="ref39">39</xref>] identified urban living as a risk factor. In addition, study by Hao et al [<xref ref-type="bibr" rid="ref42">42</xref>] on childhood adverse experiences, and study by Wu et al [<xref ref-type="bibr" rid="ref43">43</xref>] on social anxiety, findings from both of these studies received ratings of moderate methodological quality.</p><p>Intrapersonal factors significantly influence digital addiction, with our study evaluating 21 such factors, of which only 3 received moderate ratings on the AMSTAR 2 and 8 on the GRADE scale, all focusing on the associations between personality traits and digital addiction. Despite some methodological limitations, our findings were consistent with finding by Geng et al [<xref ref-type="bibr" rid="ref44">44</xref>], indicating that self-control inversely associated with digital addiction, suggesting that individuals with lower self-regulation are more prone to emotional and impulsive behaviors, thereby fostering harmful digital usage patterns. In addition, specific personality traits can serve as protective factors against digital addiction [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>]. As previous research has indicated, self-esteem, which is a reflection of an individual&#x2019;s sense of perceived value, is associated with higher self-efficacy and self-control, ultimately reducing addiction risk [<xref ref-type="bibr" rid="ref46">46</xref>]. Traits such as self-consciousness, characterized by self-discipline and organizational skills, tend to promote caution in digital interactions, favoring real-life experiences [<xref ref-type="bibr" rid="ref47">47</xref>]. Furthermore, individuals exhibiting higher levels of agreeableness and openness are less likely to encounter risks associated with digital addiction [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. Conversely, traits such as narcissism, characterized by self-centeredness and lack of empathy, may drive individuals to seek internet-based validation, increasing addiction susceptibility [<xref ref-type="bibr" rid="ref48">48</xref>]. Consistent with previous research [<xref ref-type="bibr" rid="ref49">49</xref>-<xref ref-type="bibr" rid="ref53">53</xref>], impulsivity is a notable risk factor for digital addiction, as highly impulsive individuals often struggle to resist internet-based temptations. Shyness may prompt individuals to engage more in digital socialization to avoid in-person interactions, potentially heightening addiction risk [<xref ref-type="bibr" rid="ref54">54</xref>]. Thus, our results suggest that while positive personality traits may buffer against digital addiction, negative traits can increase vulnerability. At present, cognitive behavioral therapy and psychosocial interventions are recognized as efficacious strategies for mitigating the symptoms of internet addiction. Cognitive behavioral therapy has been shown to substitute impulsive behaviors with more reasoned actions and improve self-control [<xref ref-type="bibr" rid="ref55">55</xref>], thereby contributing to the prevention and management of digital addition [<xref ref-type="bibr" rid="ref56">56</xref>]. Psychosocial interventions have been effective in addressing internet addiction and enhancing self-esteem. By focusing on the psychological and social dimensions of the individual, these approaches promote the development of a positive personality and can be effective in curbing digital addition behaviors [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]. Furthermore, gender differences are crucial, as males are more likely to develop digital addictions, likely due to their preference for strategy, role-playing, and action genres, which are inherently more addictive [<xref ref-type="bibr" rid="ref59">59</xref>].</p><p>Among the 4 interpersonal factors associated with digital addiction, 1 study was rated as moderate on both the AMSTAR 2 and GRADE scales, indicating that it provided reasonably convincing evidence through robust methodology [<xref ref-type="bibr" rid="ref8">8</xref>]. This finding is consistent with previous research, which has demonstrated that enhanced parent-child relationships can effectively reduce the risk of digital addiction among adolescents [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>]. Research suggests that there is a link between excessive parental screen time and problematic screen behaviors in their offspring. Excessive use of digital devices by parents reduces interaction with their children; this, along with their children&#x2019;s emulation of their parents&#x2019; screen-using habits, contributes to the development of screen-using behaviors in adolescents. This pattern of behavior has the potential to evolve into digital addiction [<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]. Therefore, providing guidance on the use of digital devices, especially for parents of young children, may become a viable intervention strategy to counteract the emergence of digital addiction in children.</p><p>Six of the included studies explored examined the influence of social factors on digital addiction, with 4 rated as moderate quality based on AMSTAR 2 criteria. However, only 3 of these studies received a moderate rating from GRADE. Evidence indicates that urbanization uniquely affects addiction; urban residents often face environmental pollution and discomfort associated with city life, which can heighten psychological stress and contribute to digital addiction [<xref ref-type="bibr" rid="ref64">64</xref>]. In addition, a lack of social support emerges as a critical risk factor for internet addiction. Insufficient social connections can lead to unhappiness, prompting individuals to seek emotional fulfillment through social media, potentially worsening addiction issues [<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]. Late childhood, a pivotal period for social and emotional development, shows a marked negative association between internet engagement and various well-being dimensions. This correlation suggests that the rising levels of unhappiness and anxiety in children are closely linked to increased internet use. Furthermore, adverse childhood experiences related to home environments and parental pressures significantly influence children&#x2019;s development, leading to increased time spent on digital media [[<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]]. In addition to the previously mentioned parental digital guidance, group counseling has also been reported to play a significant role in enhancing the self-control abilities of school-aged children with internet addiction [<xref ref-type="bibr" rid="ref69">69</xref>]. However, when parents are also involved in group counseling, research has proven that it requires parents to have previously successfully dealt with challenges such as social anxiety, social isolation, and social skill deficits, or else group counseling will be much less effective [<xref ref-type="bibr" rid="ref69">69</xref>].</p><p>Intrapersonal factors influencing digital addiction have been extensively studied, predominantly focusing on personality traits. However, most meta-analyses seem to suffer from methodological flaws, and even those without serious issues often reveal publication bias in original studies, thereby diminishing the quality of the evidence [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]. Therefore, it raises concerns about the risk of publication bias, where positive results are more readily published, potentially obscuring the true nature of the cause-and-effect relationship [<xref ref-type="bibr" rid="ref70">70</xref>]. In contrast, fewer studies examining interpersonal and social factors demonstrate better methodological rigor and evidence quality. These factors often exert their influence on digital addiction indirectly by affecting psychological traits or personality characteristics. For example, Malak et al [<xref ref-type="bibr" rid="ref71">71</xref>] used structural modeling to show that social support mediates the relationship between anxiety and stress, contributing to internet-based gaming disorders, a form of digital addiction [<xref ref-type="bibr" rid="ref66">66</xref>]. Thus, it is misleading to solely consider interpersonal and social factors when exploring correlates of digital addiction. Instead, this indicates the need for further research to elucidate the complex interplay between these domains.</p></sec><sec id="s4-2"><title>Limitations</title><p>While this umbrella review evaluated numerous factors associated with digital addiction, several limitations persist. First, the focus on published meta-analyses may lead to the omission of factors that are less studied or have not garnered significant attention [<xref ref-type="bibr" rid="ref72">72</xref>]. Second, the broad scope of the review complicates the generalization of results due to the diversity of research findings included. Finally, many systematic reviews analyzed similar exposure factors and were conducted within a relatively short timeframe, resulting in potential overlap among initial studies. To mitigate this, we prioritized the inclusion of the most recent meta-analyses with the highest number of studies and aimed to exclude those exhibiting considerable overlap with original studies.</p></sec><sec id="s4-3"><title>Conclusion</title><p>In conclusion, a range of intrapersonal, interpersonal, and social factors significantly influences an individual&#x2019;s susceptibility to digital addiction. A rigorous evaluation using the AMSTAR and GRADE frameworks identified negative parent-child relationships, urban residence, adverse childhood experiences, and social anxiety as credible risk factors. These findings are essential for informing effective public health strategies aimed at preventing digital addiction. However, further refinement of the methodologies used to analyze these factors is necessary to enhance the robustness of future research.</p></sec></sec></body><back><ack><p>This study was supported by the National Natural Science Foundation of China (No 82473613) and Guangdong Basic and Applied Basic Research Foundation (No 2023A1515030155). The funding sponsors had no role in the design of the study, the collection, analyses, or interpretation of data, the writing of the manuscript, and the decision to publish the results.</p></ack><fn-group><fn fn-type="con"><p>Authors YH and JQ are recognized as co-first authors of this paper, as they equally contributed to this work, whereas, authors D-LL, PL, and FZ are recognized as co-corresponding authors of this paper. The contact details for the co-corresponding authors are listed below:</p><p>Da-lin Lu, Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601, Huangpu Avenue West, Tianhe District, Guangzhou, 510632, China. Phone: +86 20 85221343; Fax: +86 20 85221343. Email: <ext-link ext-link-type="uri" xlink:href="https://mailto:dalinlu@jnu.edu.cn/">dalinlu@jnu.edu.cn</ext-link></p><p>Peng Lu, Chinese Language and Culture College, Huaqiao University, No. 668 Jimei Avenue, Jimei District, Xiamen, 361021, China. Phone: +86 18750922477; Fax: +86 0592-6683217. Email: <ext-link ext-link-type="uri" xlink:href="https://mailto:lupeng@hqu.edu.cn/">lupeng@hqu.edu.cn</ext-link></p><p>Fangfang Zeng, Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601, Huangpu Avenue West, Tianhe District, Guangzhou, 510632, China. Phone: +86 20 85221343; Fax: +86 20 85221343. Email: <ext-link ext-link-type="uri" xlink:href="https://mailto:zengffjnu@126.com/">zengffjnu@126.com</ext-link></p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">AMSTAR 2</term><def><p>A Measurement Tool to Assess Systematic Reviews 2</p></def></def-item><def-item><term id="abb2">GRADE</term><def><p>Grading of Recommendations Assessment, Development, and Evaluation</p></def></def-item><def-item><term id="abb3">JBI checklist</term><def><p>Joanna Briggs Institution Critical Appraisal Checklist</p></def></def-item><def-item><term id="abb4">NOS</term><def><p>New Castle-Ottawa scale</p></def></def-item><def-item><term id="abb5">OR</term><def><p>odds ratio</p></def></def-item><def-item><term id="abb6">PRISMA</term><def><p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p></def></def-item><def-item><term id="abb7">SSE</term><def><p>small study 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