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<?covid-19-tdm?>
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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMH</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Ment Health</journal-id>
      <journal-title>JMIR Mental Health</journal-title>
      <issn pub-type="epub">2368-7959</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v8i3e26550</article-id>
      <article-id pub-id-type="pmid">33650985</article-id>
      <article-id pub-id-type="doi">10.2196/26550</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Digital Interventions to Support Population Mental Health in Canada During the COVID-19 Pandemic: Rapid Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Torous</surname>
            <given-names>John</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Venkateswaran</surname>
            <given-names>Mahima</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>van Mierlo</surname>
            <given-names>Trevor</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Poss-Doering</surname>
            <given-names>Regina</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Strudwick</surname>
            <given-names>Gillian</given-names>
          </name>
          <degrees>RN, PhD, FAMIA</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Centre for Addiction and Mental Health</institution>
            <addr-line>1001 Queen St W</addr-line>
            <addr-line>Toronto, ON, M6J 1H4</addr-line>
            <country>Canada</country>
            <phone>1 416 535 8501</phone>
            <email>gillian.strudwick@camh.ca</email>
          </address>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-1080-7372</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Sockalingam</surname>
            <given-names>Sanjeev</given-names>
          </name>
          <degrees>MD, MHPE</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-9626-1509</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Kassam</surname>
            <given-names>Iman</given-names>
          </name>
          <degrees>MHI</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9920-3243</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Sequeira</surname>
            <given-names>Lydia</given-names>
          </name>
          <degrees>MHI</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2715-3918</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Bonato</surname>
            <given-names>Sarah</given-names>
          </name>
          <degrees>MIS</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-5174-0047</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Youssef</surname>
            <given-names>Alaa</given-names>
          </name>
          <degrees>BSc</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6505-8236</ext-link>
        </contrib>
        <contrib id="contrib7" contrib-type="author">
          <name name-style="western">
            <surname>Mehta</surname>
            <given-names>Rohan</given-names>
          </name>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2550-9941</ext-link>
        </contrib>
        <contrib id="contrib8" contrib-type="author">
          <name name-style="western">
            <surname>Green</surname>
            <given-names>Nadia</given-names>
          </name>
          <degrees>RN, MN</degrees>
          <xref rid="aff4" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-3100-5819</ext-link>
        </contrib>
        <contrib id="contrib9" contrib-type="author">
          <name name-style="western">
            <surname>Agic</surname>
            <given-names>Branka</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9765-1296</ext-link>
        </contrib>
        <contrib id="contrib10" contrib-type="author">
          <name name-style="western">
            <surname>Soklaridis</surname>
            <given-names>Sophie</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5119-8473</ext-link>
        </contrib>
        <contrib id="contrib11" contrib-type="author">
          <name name-style="western">
            <surname>Impey</surname>
            <given-names>Danielle</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff5" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-8097-5195</ext-link>
        </contrib>
        <contrib id="contrib12" contrib-type="author">
          <name name-style="western">
            <surname>Wiljer</surname>
            <given-names>David</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2748-2658</ext-link>
        </contrib>
        <contrib id="contrib13" contrib-type="author">
          <name name-style="western">
            <surname>Crawford</surname>
            <given-names>Allison</given-names>
          </name>
          <degrees>MD, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-1320-0664</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Centre for Addiction and Mental Health</institution>
        <addr-line>Toronto, ON</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>University of Toronto</institution>
        <addr-line>Toronto, ON</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>University Health Network</institution>
        <addr-line>Toronto, ON</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>University of Alberta</institution>
        <addr-line>Edmonton, AB</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff5">
        <label>5</label>
        <institution>Mental Health Commission of Canada</institution>
        <addr-line>Ottawa, ON</addr-line>
        <country>Canada</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Gillian Strudwick <email>gillian.strudwick@camh.ca</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>3</month>
        <year>2021</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>2</day>
        <month>3</month>
        <year>2021</year>
      </pub-date>
      <volume>8</volume>
      <issue>3</issue>
      <elocation-id>e26550</elocation-id>
      <history>
        <date date-type="received">
          <day>16</day>
          <month>12</month>
          <year>2020</year>
        </date>
        <date date-type="rev-request">
          <day>7</day>
          <month>1</month>
          <year>2021</year>
        </date>
        <date date-type="rev-recd">
          <day>18</day>
          <month>1</month>
          <year>2021</year>
        </date>
        <date date-type="accepted">
          <day>10</day>
          <month>2</month>
          <year>2021</year>
        </date>
      </history>
      <copyright-statement>©Gillian Strudwick, Sanjeev Sockalingam, Iman Kassam, Lydia Sequeira, Sarah Bonato, Alaa Youssef, Rohan Mehta, Nadia Green, Branka Agic, Sophie Soklaridis, Danielle Impey, David Wiljer, Allison Crawford. Originally published in JMIR Mental Health (http://mental.jmir.org), 02.03.2021.</copyright-statement>
      <copyright-year>2021</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Mental Health, is properly cited. The complete bibliographic information, a link to the original publication on http://mental.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://mental.jmir.org/2021/3/e26550" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>The COVID-19 pandemic has resulted in a number of negative health related consequences, including impacts on mental health. More than 22% of Canadians reported that they had felt depressed in the last week, in response to a December 2020 national survey. Given the need to physically distance during the pandemic, and the increase in demand for mental health services, digital interventions that support mental health and wellness may be beneficial.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>The purpose of this research was to identify digital interventions that could be used to support the mental health of the Canadian general population during the COVID-19 pandemic. The objectives were to identify (1) the populations these interventions were developed for, inclusive of exploring areas of equity such as socioeconomic status, sex/gender, race/ethnicity and culture, and relevance to Indigenous peoples and communities; (2) the effect of the interventions; and (3) any barriers or facilitators to the use of the intervention.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>This study was completed using a Cochrane Rapid Review methodology. A search of Embase, PsycInfo, Medline, and Web of Science, along with Google, Million Short, and popular mobile app libraries, was conducted. Two screeners were involved in applying inclusion criteria using Covidence software. Academic articles and mobile apps identified were screened using the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields resource, the American Psychiatric Association App Evaluation Framework, and the Mental Health Commission of Canada’s guidance on app assessment and selection.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>A total of 31 mobile apps and 114 web-based resources (eg, telemedicine, virtual peer support groups, discussion forums, etc) that could be used to support the mental health of the Canadian population during the pandemic were identified. These resources have been listed on a publicly available website along with search tags that may help an individual make a suitable selection. Variability exists in the populations that the interventions were developed for, and little assessment has been done with regard to areas of equity. The effect of the interventions was not reported for all those identified in this synthesis; however, for those that did report the effect, it was shown that they were effective in the context that they were used. A number of barriers and facilitators to using these interventions were identified, such as access, cost, and connectivity.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>A number of digital interventions that could support population mental health in Canada during the global COVID-19 pandemic were identified, indicating that individuals have several options to choose from. These interventions vary in their purpose, approach, design, cost, and targeted user group. While some research and digital interventions addressed equity-related considerations, more research and focused attention should be given to this area.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>digital health</kwd>
        <kwd>psychiatry</kwd>
        <kwd>mental health</kwd>
        <kwd>informatics</kwd>
        <kwd>pandemic</kwd>
        <kwd>COVID-19</kwd>
        <kwd>telemedicine</kwd>
        <kwd>eHealth</kwd>
        <kwd>public health</kwd>
        <kwd>virtual care</kwd>
        <kwd>mobile apps</kwd>
        <kwd>population health</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Prior to the onset of the COVID-19 pandemic, 20% of Canadians were estimated to experience a mental illness in any given year [<xref ref-type="bibr" rid="ref1">1</xref>]. In addition, 1 in 3 Canadians were expected to experience a mental illness during their lifetime [<xref ref-type="bibr" rid="ref2">2</xref>]. The probability of experiencing mental illness or having suboptimal mental health was found to be significantly more likely for Canadians within socially and economically marginalized populations [<xref ref-type="bibr" rid="ref3">3</xref>]. As a result of the COVID-19 pandemic, and the uncertainty, fear, and stress created during this unprecedented time, concern has been raised both in the media and academic literature regarding the emerging and concerning mental health crisis within Canada [<xref ref-type="bibr" rid="ref4">4</xref>]. The economic hardship, isolation, and social distancing measures enacted to slow the virus spread have inadvertently introduced a number of mental health consequences, including increased feelings of anxiety, depression, distress, insomnia, and burnout [<xref ref-type="bibr" rid="ref5">5</xref>]. The decline in population mental health appears to be a direct result of the worsening public health crisis, which has been detrimental to both Canadian and international populations.</p>
        <p>Data from several countries have identified increased risk and burden of mental health distress during COVID-19. A recent survey from the United States found that the prevalence of depression symptoms increased more than 3-fold during the pandemic [<xref ref-type="bibr" rid="ref6">6</xref>]. Prior to the pandemic, 8.5% of individuals in the United States expressed feelings of depression; this number increased to 27.8% during the COVID-19 pandemic [<xref ref-type="bibr" rid="ref6">6</xref>]. The study also found that individuals in lower-income brackets were 1.5 times more likely to experience symptoms of depression in comparison to those in higher-income groups [<xref ref-type="bibr" rid="ref6">6</xref>]. Furthermore, a survey conducted by the Centers for Disease Control and Prevention of US citizens concluded that the adverse mental health impacts created by the COVID-19 pandemic have disproportionately affected marginalized populations, specifically those who identify as persons of color, younger adults, caregivers, and those with pre-existing mental health conditions [<xref ref-type="bibr" rid="ref7">7</xref>]. Similarly, symptoms of depression, anxiety, and stress increased during the first 4-6 weeks of social distancing and isolation measures in the United Kingdom [<xref ref-type="bibr" rid="ref8">8</xref>]. The substantial decline in mental well-being in the United Kingdom shows a comparable pattern to the United States, with disproportionate and inequitable impact on marginalized populations. There is a significantly higher prevalence of mental distress among individuals who have pre-existing physical and mental health conditions, those who identify as persons of color, and those in lower-income brackets [<xref ref-type="bibr" rid="ref9">9</xref>]. The international mental health effects of the COVID-19 pandemic are also evident in the Canadian population [<xref ref-type="bibr" rid="ref10">10</xref>].</p>
        <p>A recent survey conducted by the Centre for Addiction and Mental Health (CAMH), in December 2020, found that 24% of Canadians experienced moderate to severe anxiety, 23% felt lonely, and 22% felt depressed as a result of COVID-19 [<xref ref-type="bibr" rid="ref11">11</xref>]. Women experienced worse mental health outcomes in comparison to men, where 25% of women reported feeling more depressed, anxious, and lonely during the pandemic period [<xref ref-type="bibr" rid="ref12">12</xref>]. Moreover, thoughts and feelings of suicide in the Canadian population have notably risen since the onset of COVID-19, whereby 6% of the Canadian population experienced thoughts or feelings of suicide [<xref ref-type="bibr" rid="ref13">13</xref>]. In comparison to the general Canadian population, Indigenous peoples and communities, individuals with pre-existing mental health conditions, and individuals in lower-income brackets were 2 to 4 times more likely to have thoughts or feelings of suicide [<xref ref-type="bibr" rid="ref13">13</xref>]. The lasting impact of the COVID-19 pandemic on the mental health and well-being of Canadians warrants concern as individuals, primarily vulnerable and marginalized populations, are already at greater risk of developing severe and chronic mental health disorders [<xref ref-type="bibr" rid="ref14">14</xref>].</p>
        <p>Stressors created by enforced social distancing and isolation measures have applied further pressure on an already overburdened, strained, and limited Canadian mental health care system [<xref ref-type="bibr" rid="ref10">10</xref>]. Despite the recognizable need for increased mental health supports, available mental health services are not adequate to support this increased volume of need through conventional services such as face-to-face care [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref16">16</xref>]. In addition, due to constraints posed by COVID-19, it is no longer feasible or appropriate to provide in-person mental health care services under many circumstances [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref16">16</xref>]. Where face-to-face interventions are offered, these currently address acute and severe decompensation of mental health. There is a need to support the adaptation, transformation, and augmentation of our current infrastructure to increase capacity and ideally to support mental health and wellness at a population health level [<xref ref-type="bibr" rid="ref10">10</xref>].</p>
        <p>Digital interventions created in the response to COVID-19 are potential solutions to support population mental health during and after the pandemic. By digital interventions, we refer to those in the World Health Organization’s (WHO) classification of digital health technologies [<xref ref-type="bibr" rid="ref17">17</xref>], as well as the types outlined by the Mental Health Commission of Canada (MHCC) [<xref ref-type="bibr" rid="ref18">18</xref>] such as websites, web-based programs, electronic knowledge platforms, mobile health apps (inclusive of texting), telemedicine, and social media. Digital interventions enable the provision of convenient and timely mental health care services and support through digital means. Digital interventions that have been created for non–COVID-19–related purposes (eg, for natural and human-made disasters, other pandemics) may also be relevant to support population mental health. This approach has been utilized for the identification of nondigital interventions during the COVID-19 pandemic [<xref ref-type="bibr" rid="ref19">19</xref>].</p>
      </sec>
      <sec>
        <title>Research Question and Objectives</title>
        <p>The following research question was asked: what digital interventions could be used to support the mental health of the Canadian general population during the COVID-19 pandemic?</p>
        <p>The objectives of the study were the following:</p>
        <list list-type="order">
          <list-item>
            <p>To identify populations that digital interventions might impact. We are specifically interested in understanding key equity areas related to sex/gender, socioeconomic status, race/ethnicity and culture, and relevance to Indigenous peoples and communities;</p>
          </list-item>
          <list-item>
            <p>To determine what is known about the effect of these digital interventions and for whom;</p>
          </list-item>
          <list-item>
            <p>To identify barriers and facilitators to the use of these digital interventions.</p>
          </list-item>
        </list>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <p>We conducted a rapid review of the academic and gray literature using the interim guidance from the Cochrane Rapid Reviews Methods Group with minor modifications made where appropriate [<xref ref-type="bibr" rid="ref20">20</xref>].</p>
      <sec>
        <title>Search Strategy</title>
        <p>For the academic searches, our librarian team member created detailed search strategies and executed searches for Embase, PsycInfo, Medline, and Web of Science. We have included the preliminary search strategy for Medline in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>. Search strategies for other databases were developed based on the Medline search strategy approach. For the gray literature review, we conducted searches of smartphone app stores, curated smartphone app libraries, and structured Google searches [<xref ref-type="bibr" rid="ref21">21</xref>]. We conducted a brainstorming session with 3 members of the investigator team, inclusive of a person with lived experience of mental health problems or illnesses to develop a list of key terms the public may search when looking for smartphone apps to support their mental health during COVID-19. The list of key terms was then presented to and approved by the larger study team. The Google Play Store and Apple’s App Store were searched using the terms identified during the brainstorming session. The top 10 smartphone apps per search term were included in this review.</p>
        <p>We searched the following curated smartphone libraries: Practical Apps, Alberta Health Services App Library, Scarborough Health Network Mental Health App Library, eMentalhealth.ca, King’s Western University Library, Health Navigator New Zealand, NHS App Library, and One Mind Psyberguide. A gray literature search on Google using a structured Google search was also completed (search string: COVID + Mental Health + apps). The structured Google search methodology aimed to identify information from a diverse range of locations to account for the personalization of Google search results [<xref ref-type="bibr" rid="ref22">22</xref>]. Our librarian team member conducted structured searches of Google and Million Short search engines to identify web-based resources and/or smartphone apps that may support population mental health during COVID-19. Million Short, a Canadian web search engine, was used in addition to Google, as it identifies websites that would otherwise not be highly ranked in other search engine results [<xref ref-type="bibr" rid="ref23">23</xref>]. We reviewed the first 30 search findings (unique websites) from the 62 searches completed using the Google Chrome web browser. Paid ads were not present within the searches completed. A complete list of Google and Million Short search strings are available in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>.</p>
      </sec>
      <sec>
        <title>Inclusion Criteria</title>
        <p>The following inclusion criteria were utilized for academic searches:</p>
        <list list-type="bullet">
          <list-item>
            <p>Academic articles must describe a digital mental health intervention;</p>
          </list-item>
          <list-item>
            <p>Digital interventions are classified based on both the MHCC technology types [<xref ref-type="bibr" rid="ref18">18</xref>], and the WHO classification of digital interventions [<xref ref-type="bibr" rid="ref17">17</xref>]. The MHCC and WHO classifications were mapped to one another. <xref ref-type="table" rid="table1">Table 1</xref> presents the mapped breakdown of digital health intervention types;</p>
          </list-item>
          <list-item>
            <p>Published since 2000;</p>
          </list-item>
          <list-item>
            <p>Written in English;</p>
          </list-item>
          <list-item>
            <p>Described a population mental health treatment, assessment, promotion, or prevention intervention, inclusive of promoting mental well-being and delivering mental health services;</p>
          </list-item>
          <list-item>
            <p>Relevant to the COVID-19 context (eg, natural disasters, man-made disasters, other medical pandemics, etc) [<xref ref-type="bibr" rid="ref19">19</xref>]. Web-based resources that were COVID-19 specific were included;</p>
          </list-item>
          <list-item>
            <p>Research articles, commentaries, reviews, and nonresearch articles were included.</p>
          </list-item>
        </list>
        <p>The following inclusion criteria were utilized for gray literature searches:</p>
        <list list-type="bullet">
          <list-item>
            <p>Available for use within Canada by the general public;</p>
          </list-item>
          <list-item>
            <p>Developed specifically for or modified for the COVID-19 pandemic. Resources that were modified for the COVID-19 pandemic include:</p>
            <list list-type="bullet">
              <list-item>
                <p>Resources that have been suggested as a mental wellness resource during the pandemic;</p>
              </list-item>
              <list-item>
                <p>Resources that have been updated during COVID-19 to include relevant mental health resources (eg, included a statement or indication that the resource can be used to support one’s mental health during COVID-19);</p>
              </list-item>
              <list-item>
                <p>Resources that gave away a free trial, subscription, or section of their app or web-based intervention during the COVID-19 pandemic.</p>
              </list-item>
            </list>
          </list-item>
        </list>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Mapped classification of digital health interventions using the Mental Health Commission of Canada (MHCC) and World Health Organization (WHO) technology classifications.</p>
          </caption>
          <table border="1" rules="groups" cellpadding="5" frame="hsides" width="1000" cellspacing="0">
            <col width="500"/>
            <col width="500"/>
            <thead>
              <tr valign="top">
                <td>WHO classification of digital health interventions for clients</td>
                <td>MHCC types of e-mental health technologies</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Targeted client communication</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>App, website</p>
                    </list-item>
                    <list-item>
                      <p>Instant messaging</p>
                    </list-item>
                    <list-item>
                      <p>Social media</p>
                    </list-item>
                    <list-item>
                      <p>Portal/electronic medical record</p>
                    </list-item>
                    <list-item>
                      <p>Smartphone, wearable</p>
                    </list-item>
                    <list-item>
                      <p>Artificial intelligence, big data</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Untargeted client communication</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>App, website</p>
                    </list-item>
                    <list-item>
                      <p>Instant messaging</p>
                    </list-item>
                    <list-item>
                      <p>Social media</p>
                    </list-item>
                    <list-item>
                      <p>Portal/electronic medical record</p>
                    </list-item>
                    <list-item>
                      <p>Smartphone, wearable</p>
                    </list-item>
                    <list-item>
                      <p>Artificial intelligence, big data</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Client to client communication</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>App, website</p>
                    </list-item>
                    <list-item>
                      <p>Instant messaging</p>
                    </list-item>
                    <list-item>
                      <p>Social media</p>
                    </list-item>
                    <list-item>
                      <p>Smartphone, wearable</p>
                    </list-item>
                    <list-item>
                      <p>Artificial intelligence, big data</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Personal health tracking</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Portal/electronic medical record</p>
                    </list-item>
                    <list-item>
                      <p>Smartphone, wearable</p>
                    </list-item>
                    <list-item>
                      <p>Artificial intelligence, big data</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Citizen based reporting</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>App, Website</p>
                    </list-item>
                    <list-item>
                      <p>Instant messaging</p>
                    </list-item>
                    <list-item>
                      <p>Social media</p>
                    </list-item>
                    <list-item>
                      <p>Smartphone</p>
                    </list-item>
                    <list-item>
                      <p>Artificial intelligence, big data</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>On-demand information services to clients</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Search engine</p>
                    </list-item>
                    <list-item>
                      <p>Artificial intelligence, big data</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Telemedicine</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Telehealth</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>Screening Process</title>
        <p>To calibrate the application of inclusion criteria to the identified citations in the academic literature review, 2 members of the investigator team applied the criteria independently to 30 citations ensuring an appropriate level of agreement (&#62;80%) before further screening was conducted. The remaining citations were divided between the 2 screeners to ensure a rapid approach to citation screening. This was facilitated by an online system called Covidence [<xref ref-type="bibr" rid="ref24">24</xref>] and was done in the following stages:</p>
        <list list-type="bullet">
          <list-item>
            <p>Stage 1: citations identified from the academic database searches were uploaded into Covidence for screening;</p>
          </list-item>
          <list-item>
            <p>Stage 2: the abstracts and titles of all citations were screened utilizing the predetermined inclusion criteria. Questions regarding the eligibility of citations were discussed between the screeners, and the nominated principal applicant was consulted if a discrepancy was found;</p>
          </list-item>
          <list-item>
            <p>Stage 3: the remaining citations had the inclusion criteria applied by the screeners to the full text;</p>
          </list-item>
          <list-item>
            <p>Stage 4: preliminary data was then extracted from the articles that were included after the full-text screening was completed and entered into a data extraction table to assist with data synthesis.</p>
          </list-item>
        </list>
      </sec>
      <sec>
        <title>Data Synthesis</title>
        <p>For the included academic literature, a data extraction table was created that captured basic article characteristics and results related to the research question and objectives. To identify populations that may be impacted by the digital intervention, we also collected information pertaining to the following equity-related areas: (1) Indigenous peoples and communities, (2) gender/sex, (3) race/ethnicity and culture, and (4) socioeconomic status. For apps and web-based resources, a data extraction table was created that captured basic details of the interventions (eg, target population, cost) and their specific purpose(s). Synthesis of the data from the data extraction tables was done using thematic analysis and descriptive statistics.</p>
      </sec>
      <sec>
        <title>Quality Assessment</title>
        <p>We conducted a quality assessment of the included articles using the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields resource (Kmet criteria) [<xref ref-type="bibr" rid="ref25">25</xref>]. We also carried out an evaluation of the included mobile apps using the American Psychiatric Association’s App Evaluation Model [<xref ref-type="bibr" rid="ref26">26</xref>], while leveraging the app evaluation website developed by the Division of Digital Psychiatry at the Beth Israel Deaconess Medical Center [<xref ref-type="bibr" rid="ref27">27</xref>]. For those apps that did not have an evaluation present within the website, we carried out our own evaluation using the App Evaluation Model. This was also informed by the MHCC’s guidance on app assessment and selection [<xref ref-type="bibr" rid="ref28">28</xref>]. Regarding the website resources, no quality assessment was performed primarily due to the volume and variety of identified website resources (eg, telemedicine, virtual peer support groups, discussion forums, etc).</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Academic Literature Findings</title>
        <p>Results of the academic search are summarized in a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram shown in <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>. We found a total of 70 articles that met our inclusion criteria. While many articles specifically addressed COVID-19 (n=42, 60%), others were related to natural disasters (n=19, 27%) and human-made disasters (n=9, 14%). Most of the COVID-19–specific articles were commentaries or viewpoints (n=32, 46%). A total of 25 (36%) were primary studies and 13 (18%) were reviews. Identified articles originated primarily from the United States (n=39) but were also from China (n=6), Australia (n=4), the United Kingdom (n=4), India (n=2), Italy (n=2), New Zealand (n=2), Brazil (n=1), Canada (n=1), Croatia (n=1), Indonesia (n=1), Iraq (n=1), Ireland (n=1), Israel (n=1), the Netherlands (n=1), Pakistan (n=1), Spain (n=1), and Taiwan (n=1). A full data extraction table of all included articles is available upon request from the corresponding author.</p>
      </sec>
      <sec>
        <title>Gray Search Findings</title>
        <p>We found 174 smartphone apps in our initial search. A total of 135 were identified through curated libraries, 19 via searches in the Google Play Store and Apple’s App Store, and 20 through web-based searches. Once the inclusion criteria were applied, a total of 31 mobile apps and 114 web-based resources were found. A complete list of the identified mobile apps and web-based resources can be found on the CAMH website [<xref ref-type="bibr" rid="ref29">29</xref>].</p>
      </sec>
      <sec>
        <title>Identified Interventions</title>
        <p>A list of digital interventions and their respective purposes is shown in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>. This includes smartphone apps and web-based resources that mirror the technology categories of the WHO classification and MHCC technology typology.</p>
      </sec>
      <sec>
        <title>Populations That Might Benefit From or Be Disadvantaged by the Identified Digital Interventions</title>
        <p>Most interventions impacted those with access to a device (eg, smartphone, laptop, or tablet) and an internet connection (cell phone data or wireless). Four interventions involved shifting away from in-person care to providing mental health care virtually through telemedicine platforms, videoconferencing platforms (eg, Zoom [<xref ref-type="bibr" rid="ref30">30</xref>]), or in-house platforms during the COVID-19 pandemic [<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref34">34</xref>]. Such interventions benefited those with a private or safe space to engage in their care [<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref34">34</xref>]. Conversely, populations that were at a disadvantage for making use of digital interventions included those who lacked the appropriate technology or internet access (including older adults who may not be able to effectively use technology) and those living in unsafe conditions or lacking access to a private space. Additionally, most of these interventions offered regular services for existing clients, so new clients were at a disadvantage, as well as those in need of acute care.</p>
        <p>There were 10 web-based mental health interventions focused on remote populations [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>] and adapted for Indigenous peoples (First Nations, Inuit, and Métis) [<xref ref-type="bibr" rid="ref36">36</xref>], victims of sexual abuse [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>], adolescents and caregivers [<xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref40">40</xref>], and survivors of specific trauma [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref43">43</xref>]. While these advantaged a variety of populations, a few were available only in English and hence those who did not speak the language were at a disadvantage. A mobile app that focused on connection between family members and seniors [<xref ref-type="bibr" rid="ref44">44</xref>] was available for English, Spanish, and French speakers, but, like the previously mentioned interventions, were limited to those with the know-how and technology to use it.</p>
        <p>Two COVID-19–specific interventions—telephone and television support [<xref ref-type="bibr" rid="ref45">45</xref>]—were advantageous for older adults and their caregivers; phone services were beneficial for individuals with substance use or opioid disorder [<xref ref-type="bibr" rid="ref46">46</xref>]. In general, hotlines or phone-support interventions (including the three developed prior to COVID-19) [<xref ref-type="bibr" rid="ref47">47</xref>-<xref ref-type="bibr" rid="ref49">49</xref>] helped to expand the population to those with access to a landline or basic phone plan, including those living in transitory circumstances.</p>
        <p>A high-risk population that emerged within our findings was veterans. Veterans were advantaged by targeted supports, including veteran-specific telemedicine programs [<xref ref-type="bibr" rid="ref50">50</xref>], especially those who were poor, unemployed, single, or with a poor health status. Veteran-specific digital interventions such as educational and self-help resources also benefited family members [<xref ref-type="bibr" rid="ref51">51</xref>]. A thorough list of the populations advantaged and disadvantaged by the included interventions is described in <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>.</p>
        <p>We also collected additional information about the following equity-related areas: (1) Indigenous peoples and communities, (2) gender/sex, (3) race/ethnicity and culture, and (4) socioeconomic status. Belleville et al [<xref ref-type="bibr" rid="ref36">36</xref>] adapted their intervention for diverse populations including members of the First Nations, Inuit, and Métis communities. Two studies addressed sex and gender considerations, recognizing that women exhibit more help-seeking behaviors [<xref ref-type="bibr" rid="ref36">36</xref>] and were more open to sharing instances of sexual abuse [<xref ref-type="bibr" rid="ref47">47</xref>]. Three studies addressed race/ethnicity and cultural considerations, including ones that were specifically adapted to fit a non-Western population [<xref ref-type="bibr" rid="ref37">37</xref>], available in a variety of languages and offered translator services [<xref ref-type="bibr" rid="ref47">47</xref>], and targeted at veterans [<xref ref-type="bibr" rid="ref51">51</xref>]. Eleven studies considered the socioeconomic status of their end-users, providing free interventions for those who were publicly insured. Two interventions provided phone calls as an alternative to the internet [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref49">49</xref>], and one was tailored to older adults’ digital health literacy [<xref ref-type="bibr" rid="ref45">45</xref>].</p>
      </sec>
      <sec>
        <title>What Is Known About the Effect of These Digital Interventions</title>
        <p>Of the identified studies, 7 had information related to the effect of the intervention [<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]. The majority (n=6) were found to be effective in reducing symptoms of posttraumatic stress disorder (PTSD), anxiety, depression, and loneliness in the various medical, natural, and man-made disaster contexts [<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>]. For example, one study evaluated the use of a web-based mental health intervention in tornado-affected rural and urban regions of the United States [<xref ref-type="bibr" rid="ref38">38</xref>]. Findings from this study demonstrated that there were no significant differences in the uptake and completion of the web-based mental health intervention by rural and urban households. This suggests that digital interventions may be used to support the mental health of individuals residing in rural geographic areas, given these communities often lack in-person access to mental health services [<xref ref-type="bibr" rid="ref38">38</xref>]. Another study underscored the effectiveness of e-therapy (electronic therapy) in treating youth with mild to moderate anxiety. An emphasis was placed on the use of digital mental health interventions within the stepped care model to improve mental health care delivery, whereby primary care physicians can have access to a menu of digital mental health interventions to recommend to parents or caregivers concerned about their child’s emotional or behavioral well-being [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>].</p>
        <p>Several international studies, specifically an internet-based intervention for PTSD in Iraq [<xref ref-type="bibr" rid="ref37">37</xref>] and a community mental health relief program in Taiwan following an earthquake [<xref ref-type="bibr" rid="ref49">49</xref>], highlighted the uptake and effect of digital mental health resources and interventions in politically and/or physically unstable regions. Individuals affected and displaced by both war or conflict and natural disasters sought mental health support through digital means and benefited from the digital support in place of access to in-person support [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]. In addition, a television-based intervention developed for older adults during the COVID-19 pandemic was found to be effective in reducing feelings of loneliness and distress during the isolation/quarantine period [<xref ref-type="bibr" rid="ref45">45</xref>]. Adoption of and access to smartphones, TV devices, tablets, and computers facilitated connectedness and increased communication between older adults and their family members or caregivers. A summary of the effect for each of the identified interventions is described in <xref ref-type="supplementary-material" rid="app5">Multimedia Appendix 5</xref>.</p>
      </sec>
      <sec>
        <title>Barriers and Facilitators to the Use of These Digital Interventions</title>
        <p>Most included articles identified a few barriers and facilitators to the uptake and use of digital mental health interventions. These were related to the (1) technology (eg, poor connectivity, user-friendly design), (2) people using the technology (eg, knowledge about how to use the digital intervention, interest in using the intervention), and (3) context/processes in place to support or detract from the uptake of the technology (eg, a private space to use the digital intervention, organizational supports if applicable). A sample of these barriers and facilitators is shown in <xref ref-type="boxed-text" rid="box1">Textbox 1</xref>.</p>
        <boxed-text id="box1" position="float">
          <title>Barriers and facilitators to digital mental health intervention use.</title>
          <p>
            <bold>Barriers:</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Difficulty using the technology</p>
            </list-item>
            <list-item>
              <p>Mistrust of the technology or security of data</p>
            </list-item>
            <list-item>
              <p>Legislation that prevents certain forms of care (eg, harm reduction)</p>
            </list-item>
            <list-item>
              <p>Lack of data sharing/interoperability</p>
            </list-item>
            <list-item>
              <p>Difficulty establishing a therapeutic alliance between people seeking care and providers due to technology-related challenges</p>
            </list-item>
            <list-item>
              <p>Poor connectivity</p>
            </list-item>
          </list>
          <p>
            <bold>Facilitators:</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Organizational support (eg, help desk)</p>
            </list-item>
            <list-item>
              <p>Access to the technology, devices, or the software</p>
            </list-item>
            <list-item>
              <p>Access to training about the digital intervention</p>
            </list-item>
            <list-item>
              <p>Access to a specific type of mental health care</p>
            </list-item>
            <list-item>
              <p>Cost (free or provided at a limited cost)</p>
            </list-item>
            <list-item>
              <p>Ability of users to be anonymous if desired</p>
            </list-item>
          </list>
        </boxed-text>
        <p>A full list of the identified barriers and facilitators with details related to the specific type of digital intervention used is included in <xref ref-type="supplementary-material" rid="app6">Multimedia Appendix 6</xref>.</p>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This review identified that there are many digital interventions that could be used to support the mental health of the general Canadian population during the COVID-19 pandemic. These interventions vary in their purpose, approach, design, cost, and targeted user group. While some research and digital interventions addressed equity-related considerations, more research and focused attention should be paid to this area. Most digital interventions identified did not have any published data describing their effect within the context of COVID-19. The lack of data on the effectiveness is understandable given the timing of this review, which corresponds to the timing of the onset of the global pandemic (both in the same year) [<xref ref-type="bibr" rid="ref19">19</xref>].</p>
        <p>With an expanding plethora of digital mental health interventions available, with variability in cost, population focus, and type of technology used, it becomes difficult for people with lived experience of mental health problems or illnesses and providers to know which intervention to select. In addition, unawareness of the effectiveness of interventions may make clinicians wary of making specific recommendations. Fortunately, there has been some effort to support the assessment of certain types of interventions. For example the American Psychiatric Association and the MHCC both have tools to support the selection and assessment of mobile apps [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref52">52</xref>]. A recently created resource lists the various app libraries/curated lists, app rating tools, and a selection of digital mental health interventions, aimed at both providers and people with lived experience alike [<xref ref-type="bibr" rid="ref53">53</xref>]. The MHCC has also developed an implementation toolkit to support organizations in their digital mental health intervention implementations [<xref ref-type="bibr" rid="ref54">54</xref>]. Furthermore, there has been discussion regarding a role of a “digital navigator” for integrating the use of technology in practice [<xref ref-type="bibr" rid="ref55">55</xref>].</p>
        <p>While we identified several studies evaluating digital mental health interventions during disaster, crisis, or pandemic situations, there has been limited focus on equity factors that may influence the use and ability to obtain benefits from the intervention in all subpopulations. The equity factors specifically reviewed in this study included relevance and inclusivity of Indigenous peoples and communities, sex and gender, race/ethnicity and culture, and socioeconomic status.</p>
        <p>One finding of this work is the lack of resources that are specific to Indigenous peoples and communities, which is a concern in the Canadian context. To ensure that the results of future works are relevant and inclusive of Indigenous peoples and communities, a few key points should be considered. Researchers and intervention developers need to ensure that Indigenous peoples are included at every stage of development and implementation [<xref ref-type="bibr" rid="ref56">56</xref>-<xref ref-type="bibr" rid="ref59">59</xref>]. Interventions should (1) be developed by and/or with Indigenous organizations or communities; (2) implemented and evaluated by an Indigenous organization or communities; (3) developed in accordance with OCAP (Ownership, Control, Access, and Possession) principles (these principles are specific to First Nations Peoples [<xref ref-type="bibr" rid="ref60">60</xref>]); (4) stored appropriately and in a location that can be easily accessed by the engaged/involved Indigenous peoples or communities; and lastly, (5) all elements, including language, should ensure cultural relevance and safety. A list of resources to support this work can be found on the NunatuKavut website [<xref ref-type="bibr" rid="ref61">61</xref>].</p>
        <p>Other equity factors explored in this work could benefit from utilizing an appropriate framework to underpin how equity factors should be understood, examined, and evaluated. Recent work advanced by Crawford and Serhal [<xref ref-type="bibr" rid="ref62">62</xref>] provides a Digital Health Equity Framework for how future studies may approach exploring equity within a digital landscape, emphasizing the need to consider digital health within the larger contexts of socioeconomic location of individuals and communities, which are impacted by social determinants of health.</p>
      </sec>
      <sec>
        <title>Strengths and Limitations</title>
        <p>This review has several strengths and limitations. Strengths of this review included a quality appraisal of academic publications and a formal evaluation of mobile apps. Regarding limitations, this review specifically identified interventions that had been developed or modified to provide COVID-19–specific content unique to Canada. It is possible that digital mental health interventions that were developed prior to the pandemic, and without pandemic-specific content, could still be helpful. Additionally, there was great variability in the reported digital interventions, and while a quality assessment was conducted, there remains variability in the quality of the interventions available. Although we conducted several searches in a number of search engines and libraries, some digital health interventions that may meet the inclusion criteria and can support population mental health during COVID-19 might have been missed. The compiled list of interventions is not an exhaustive list of the digital mental health resources that exist to support population mental health. It presents mental health resources available to the general population and does not include those available through employment benefits programs or other workplace programs not available to the general public. In addition, the time it takes for research and publication to occur may have limited the COVID-19–specific content present in the academic literature.</p>
      </sec>
      <sec>
        <title>Conclusion</title>
        <p>Numerous digital interventions that could be used to support the mental health of the general population in Canada during the COVID-19 pandemic were identified. While there are similarities to some of the nontechnology based interventions identified in a recently published review of interventions to support mental health during emergency and disaster situations [<xref ref-type="bibr" rid="ref19">19</xref>], digital interventions present the opportunity for mental health care to be delivered at a distance. However, additional preventative measures are needed to both sustain mental wellness and to address psychological distress before severe impacts ensue. Population-based interventions are increasingly needed as a way of reducing and preventing the potential mental health impacts experienced by Canadians as a result of job loss, social isolation, changes to everyday life, both now and into the foreseeable future. To date, the interventions developed or modified to meet the current need have had minimal evaluation to determine their efficacy, as well as applicability to populations who have traditionally been disadvantaged and who continue to experience health inequities. Numerous barriers to the use of digital technology also exist for a number of individuals. Thus, a broader conversation to include concepts of equity and access is essential as these tools are developed. This rapid review demonstrates that there has been progress toward the development and adaption of digital interventions to support mental health and wellness during the COVID-19 pandemic; however, much more work needs to be done to assess the impact of these technologies.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Search strategy.</p>
        <media xlink:href="mental_v8i3e26550_app1.docx" xlink:title="DOCX File , 16 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Gray literature search strategy.</p>
        <media xlink:href="mental_v8i3e26550_app2.docx" xlink:title="DOCX File , 15 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>PRISMA flow diagram.</p>
        <media xlink:href="mental_v8i3e26550_app3.docx" xlink:title="DOCX File , 35 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>List of digital intervention purposes and populations advantaged or disadvantaged.</p>
        <media xlink:href="mental_v8i3e26550_app4.docx" xlink:title="DOCX File , 24 KB"/>
      </supplementary-material>
      <supplementary-material id="app5">
        <label>Multimedia Appendix 5</label>
        <p>Effect of digital interventions.</p>
        <media xlink:href="mental_v8i3e26550_app5.docx" xlink:title="DOCX File , 18 KB"/>
      </supplementary-material>
      <supplementary-material id="app6">
        <label>Multimedia Appendix 6</label>
        <p>Barriers and facilitators to digital intervention use.</p>
        <media xlink:href="mental_v8i3e26550_app6.docx" xlink:title="DOCX File , 19 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">e-therapy</term>
          <def>
            <p>electronic therapy</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">MHCC</term>
          <def>
            <p>Mental Health Commission of Canada</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">OCAP</term>
          <def>
            <p>Ownership, Control, Access, and Possession</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">PTSD</term>
          <def>
            <p>posttraumatic stress disorder</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">WHO</term>
          <def>
            <p>World Health Organization</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This work was funded by the Canadian Institutes of Health Research Operating Grant - Knowledge Synthesis: COVID-19 in Mental Health and Substance. The authors would also like to acknowledge the Centre for Addiction and Mental Health for in-kind support and the numerous people with lived experience and experts in the digital mental health space who provided advice, consultation, and support.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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